sel-11 E3 ubiquitin-protein ligase hrd-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sel-11
Official Full Name: E3 ubiquitin-protein ligase hrd-1
Primary source: WormBase:WBGene00004768
Locus tag: CELE_F55A11.3
See related: AllianceGenome:WB:WBGene00004768
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin protein ligase activity. Involved in regulation of Notch signaling pathway and regulation of gene expression. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum quality control compartment. Is expressed in body wall musculature; hypodermis; intestine; neurons; and pharynx. Orthologous to human SYVN1 (synoviolin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sel-11 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (11767328..11769899)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HRD-1 play essential roles in unfolded protein response (UPR) and ERAD pathways. We further found that HRD-1 functions in concert with BiP.
Title: ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F55A11.3 (e-PCR)
- UniSTS:307700

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum quality control compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase hrd-1

NP_505969.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11767328..11769899

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073568.7 → NP_505969.1 E3 ubiquitin-protein ligase hrd-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505969.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20798

Conserved Domains (2) summary

COG5243
Location:51 → 333

HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]

pfam13639
Location:291 → 333

zf-RING_2; Ring finger domain