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    cdk-12 Cyclin-dependent kinase 12 [ Caenorhabditis elegans ]

    Gene ID: 175559, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cdk-12
    Official Full Name
    Cyclin-dependent kinase 12
    Primary source
    WormBase:WBGene00007135
    Locus tag
    CELE_B0285.1
    See related
    AllianceGenome:WB:WBGene00007135
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in nematode larval development. Located in euchromatin. Is expressed in several structures, including arcade cell; germ line; head; intestine; and rectal gland cell. Human ortholog(s) of this gene implicated in congenital heart defects, dysmorphic facial features, and intellectual developmental disorder; hepatocellular carcinoma; intellectual disability; and prostate carcinoma. Orthologous to several human genes including CDK13 (cyclin dependent kinase 13). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cdk-12 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    15
    Sequence:
    Chromosome: III; NC_003281.10 (4332992..4341984)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene TMhelix containing protein Neighboring gene Ricin B lectin domain-containing protein;putative N-acetylgalactosaminyltransferase 6 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Leucine carboxyl methyltransferase 1 Neighboring gene D-glucuronyl C5-epimerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase. Boxem M, et al. Development, 1999 May. PMID 10207147
    2. RNA polymerase II CTD S2P is dispensable for embryogenesis but mediates exit from developmental diapause in C. elegans. Cassart C, et al. Sci Adv, 2020 Dec. PMID 33298437, Free PMC Article
    3. Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline. Bowman EA, et al. Development, 2013 Sep. PMID 23903194, Free PMC Article
    4. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Parry DH, et al. Curr Biol, 2007 Dec 4. PMID 18023351, Free PMC Article
    5. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Arur S, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19264959, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin-dependent kinase 12
    NP_001254916.1
    • Partially confirmed by transcript evidence
    NP_001367220.1
    • Confirmed by transcript evidence
    NP_001367221.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4332992..4341984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381836.2 → NP_001367220.1  Cyclin-dependent kinase 12 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd07864
      Location:303 → 605
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    2. NM_001381837.2 → NP_001367221.1  Cyclin-dependent kinase 12 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd07864
      Location:303 → 605
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    3. NM_001267987.3 → NP_001254916.1  Cyclin-dependent kinase 12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C8JQQ9, C8JQR0, P46551, P46552
      Conserved Domains (2) summary
      smart00220
      Location:311 → 605
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:303 → 605
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46551.4

    Gene LinkOut

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