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    rnf-5 E3 ubiquitin ligase rnf-5;RING finger protein 5;RING-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

    Gene ID: 175532, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rnf-5
    Official Full Name
    E3 ubiquitin ligase rnf-5;RING finger protein 5;RING-type E3 ubiquitin transferase
    Primary source
    WormBase:WBGene00004381
    Locus tag
    CELE_C16C10.7
    See related
    AllianceGenome:WB:WBGene00004381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ubiquitin protein ligase activity. Involved in several processes, including inductive cell migration; striated muscle cell development; and ubiquitin-dependent protein catabolic process. Located in cell junction; nucleus; and striated muscle dense body. Is expressed in head neurons; hypodermis; and tail neurons. Orthologous to human RNF185 (ring finger protein 185) and RNF5 (ring finger protein 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rnf-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (4164274..4166845, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RAP domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Nuclear speckle splicing regulatory protein 1 homolog Neighboring gene E3 ubiquitin ligase rnf-121

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inactivation of the Caenorhabditis elegans RNF-5 E3 ligase promotes IRE-1-independent ER functions. Adir O, et al. Autophagy, 2021 Sep. PMID 32981418, Free PMC Article
    2. Molting-specific downregulation of C. elegans body-wall muscle attachment sites: the role of RNF-5 E3 ligase. Zaidel-Bar R, et al. Biochem Biophys Res Commun, 2010 May 14. PMID 20385102
    3. The LIM domain protein UNC-95 is required for the assembly of muscle attachment structures and is regulated by the RING finger protein RNF-5 in C. elegans. Broday L, et al. J Cell Biol, 2004 Jun 21. PMID 15210732, Free PMC Article
    4. CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans. Kovacevic I, et al. Mech Dev, 2012 Jan-Feb. PMID 22285439, Free PMC Article
    5. RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. Didier C, et al. Mol Cell Biol, 2003 Aug. PMID 12861019, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inactivation of the Caenorhabditis elegans RNF-5 E3 ligase promotes IRE-1-independent ER functions.
      Title: Inactivation of the Caenorhabditis elegans RNF-5 E3 ligase promotes IRE-1-independent ER functions.
    2. These observations indicate that increased dense bodies (DB) dynamics characterizes the lethargus phase of molting in parallel to decreased levels of DB components and that temporal expression of RNF-5 contributes to an efficient molting process.
      Title: Molting-specific downregulation of C. elegans body-wall muscle attachment sites: the role of RNF-5 E3 ligase.
    3. UNC-95 constitutes an essential component of muscle adhesion sites that is regulated by RNF-5.
      Title: The LIM domain protein UNC-95 is required for the assembly of muscle attachment structures and is regulated by the RING finger protein RNF-5 in C. elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like protein conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inductive cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in inductive cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in striated muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin ligase rnf-5;RING finger protein 5;RING-type E3 ubiquitin transferase
    NP_001309592.1
    • Confirmed by transcript evidence
    NP_001309593.1
    • Confirmed by transcript evidence
    NP_001309594.1
    • Confirmed by transcript evidence
    NP_497830.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4164274..4166845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322782.4 → NP_001309592.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MD51
      Conserved Domains (1) summary
      cd16744
      Location:25 → 67
      RING-HC_RNF185; RING finger, HC subclass, found in RING finger protein 185 (RNF185) and similar proteins

    2. NM_065429.4 → NP_497830.1  E3 ubiquitin ligase rnf-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497830.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09463
      Conserved Domains (1) summary
      cd00162
      Location:25 → 70
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. NM_001322783.3 → NP_001309594.1  RING finger protein 5 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBQ1

    4. NM_001322784.3 → NP_001309593.1  RING finger protein 5 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBI1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09463.1

    Gene LinkOut

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