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    cua-1 P-type Cu(+) transporter [ Caenorhabditis elegans ]

    Gene ID: 176770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cua-1
    Official Full Name
    P-type Cu(+) transporter
    Primary source
    WormBase:WBGene00000834
    Locus tag
    CELE_Y76A2A.2
    See related
    AllianceGenome:WB:WBGene00000834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables copper ion transmembrane transporter activity. Involved in copper ion transport. Located in vacuolar membrane. Is expressed in hypodermis; intestine; neurons; and pharynx. Used to study Menkes disease. Human ortholog(s) of this gene implicated in Menkes disease; Wilson disease; X-linked distal spinal muscular atrophy 3; cutis laxa; and occipital horn syndrome. Orthologous to several human genes including ATP7A (ATPase copper transporting alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cua-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    16
    Sequence:
    Chromosome: III; NC_003281.10 (13439730..13455307, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene rRNA methyltransferase 2, mitochondrial Neighboring gene MIP18 family protein F45G2.10 Neighboring gene ABC transporter domain-containing protein Neighboring gene Major sperm protein Neighboring gene Cytochrome b-c1 complex subunit 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new Caenorhabditis elegans model to study copper toxicity in Wilson disease. Catalano F, et al. Traffic, 2024 Jan. PMID 37886910,
    2. Caenorhabditis elegans cDNA for a Menkes/Wilson disease gene homologue and its function in a yeast CCC2 gene deletion mutant. Sambongi Y, et al. J Biochem, 1997 Jun. PMID 9354393
    3. Essential Cys-Pro-Cys motif of Caenorhabditis elegans copper transport ATPase. Yoshimizu T, et al. Biosci Biotechnol Biochem, 1998 Jun. PMID 9692213
    4. CHCA-1 is a copper-regulated CTR1 homolog required for normal development, copper accumulation, and copper-sensing behavior in Caenorhabditis elegans. Yuan S, et al. J Biol Chem, 2018 Jul 13. PMID 29784876, Free PMC Article
    5. The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans. Chun H, et al. J Biol Chem, 2017 Jan 6. PMID 27881675, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type divalent copper transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type monovalent copper transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion export IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in copper ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in copper ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in copper ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in copper ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular copper ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    P-type Cu(+) transporter
    NP_001255202.1
    • Confirmed by transcript evidence
    NP_001255203.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13439730..13455307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268273.4 → NP_001255202.1  P-type Cu(+) transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255202.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE14, O17537
      Conserved Domains (5) summary
      COG2217
      Location:330 → 1117
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:961 → 1082
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:253 → 317
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:534 → 775
      E1-E2_ATPase; E1-E2 ATPase
      pfam00403
      Location:332 → 389
      HMA; Heavy-metal-associated domain

    2. NM_001268274.3 → NP_001255203.1  P-type Cu(+) transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED40, O17537
      Conserved Domains (5) summary
      COG2217
      Location:208 → 995
      ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
      COG4087
      Location:839 → 960
      COG4087; Soluble P-type ATPase [General function prediction only]
      cd00371
      Location:131 → 195
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      pfam00122
      Location:412 → 653
      E1-E2_ATPase; E1-E2 ATPase
      pfam00403
      Location:210 → 267
      HMA; Heavy-metal-associated domain
    Nucleotide Protein
    Heading Accession and Version

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