abl-1 F-actin binding domain-containing protein;Tyrosine-protein kinase;Tyrosine-protein kinase abl-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: abl-1
Official Full Name: F-actin binding domain-containing protein;Tyrosine-protein kinase;Tyrosine-protein kinase abl-1
Primary source: WormBase:WBGene00000018
Locus tag: CELE_M79.1
See related: AllianceGenome:WB:WBGene00000018
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including defense response to other organism; negative regulation of DNA damage response, signal transduction by p53 class mediator; and negative regulation of engulfment of apoptotic cell. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in Q cell; germ cell; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple) and leukemia (multiple). Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) and ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See abl-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 19

Sequence:: Chromosome: X; NC_003284.9 (10605827..10624207, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MIG-13-WAVE pathway provides the major force for directional cell motility, whereas MIG-13-WASP partially compensates for its loss, underscoring their coordinated activities in facilitating robust cell migration.
Title: Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration.
By screening candidate genes involved in Eph signaling, we find that the Eph kinase-independent pathway involves the ABL-1 nonreceptor tyrosine kinase and possibly the phosphatidylinositol 3-kinase pathway
Title: Mechanisms of ephrin receptor protein kinase-independent signaling in amphid axon guidance in Caenorhabditis elegans.
The trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1.
Title: A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.
oxidative, osmotic, heat shock and starvation stresses induce germ cell apoptosis through a p53 and EGL-1 independent pathway; the MAPK kinases MEK-1 and SEK-1, and the p53 antagonist protein ABL-1, are essential for stress-induced germ cell apoptosis
Title: Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans.
findings demonstrate that ABL-1, the C. elegans homolog of the mammalian c-Abl nonreceptor tyrosine kinase ABL1, is required for Shigella flexneri pathogenesis in nematodes
Title: The Caenorhabditis elegans ABL-1 tyrosine kinase is required for Shigella flexneri pathogenesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M79.1 (e-PCR)
- UniSTS:312012

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell communication	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of engulfment of apoptotic cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signaling	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F-actin binding domain-containing protein;Tyrosine-protein kinase;Tyrosine-protein kinase abl-1

NP_001368775.1

Confirmed by transcript evidence

NP_001368776.1

Confirmed by transcript evidence

NP_001391194.1

Confirmed by transcript evidence

NP_001407512.1

Confirmed by transcript evidence

NP_001407513.1

Confirmed by transcript evidence

NP_509777.2

Confirmed by transcript evidence

NP_509778.2

Confirmed by transcript evidence

NP_509779.2

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

10605827..10624207 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077376.10 → NP_509777.2 Tyrosine-protein kinase abl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509777.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P03949

Conserved Domains (5) summary

smart00808
Location:1081 → 1214

FABD; F-actin binding domain (FABD)

cd09935
Location:180 → 273

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:109 → 175

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:294 → 556

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:301 → 552

Pkinase_Tyr; Protein tyrosine kinase
NM_077377.7 → NP_509778.2 Tyrosine-protein kinase abl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509778.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P03949, Q9U3A2, Q9U3A3

Conserved Domains (5) summary

smart00808
Location:1091 → 1224

FABD; F-actin binding domain (FABD)

cd09935
Location:190 → 283

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:119 → 185

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:304 → 566

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:311 → 562

Pkinase_Tyr; Protein tyrosine kinase
NM_001381087.2 → NP_001368775.1 Tyrosine-protein kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5E4LZL8

Conserved Domains (4) summary

smart00808
Location:1087 → 1220

FABD; F-actin binding domain (FABD)

cd09935
Location:190 → 283

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:119 → 185

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:304 → 566

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
NM_001381086.2 → NP_001368776.1 Tyrosine-protein kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5E4LZH0

Conserved Domains (4) summary

smart00808
Location:1077 → 1210

FABD; F-actin binding domain (FABD)

cd09935
Location:180 → 273

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:109 → 175

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:294 → 556

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
NM_077378.5 → NP_509779.2 Tyrosine-protein kinase abl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509779.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P03949

Conserved Domains (5) summary

smart00808
Location:1076 → 1209

FABD; F-actin binding domain (FABD)

cd09935
Location:175 → 268

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:104 → 170

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:289 → 551

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:296 → 547

Pkinase_Tyr; Protein tyrosine kinase
NM_001420574.1 → NP_001407513.1 Tyrosine-protein kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QCL3
NM_001420575.1 → NP_001407512.1 Tyrosine-protein kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QC30
NM_001404207.1 → NP_001391194.1 F-actin binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QGR5