sec-61.B Protein transport protein Sec61 subunit beta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sec-61.B
Official Full Name: Protein transport protein Sec61 subunit beta
Primary source: WormBase:WBGene00021427
Locus tag: CELE_Y38F2AR.9
See related: AllianceGenome:WB:WBGene00021427
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and post-translational protein targeting to membrane, translocation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Predicted to be active in membrane. Orthologous to human SEC61B (SEC61 translocon subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sec-61.B in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 2

Sequence:: Chromosome: IV; NC_003282.8 (2388185..2388675, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sec61beta may stabilize protein translocation by linking translocon complex to microtubule and provide insight into the physiological function of ER-microtubule interaction
Title: Sec61β facilitates the maintenance of endoplasmic reticulum homeostasis by associating microtubules.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y38F2A_6126.i (e-PCR)
- UniSTS:323637

Y38F2A_6126.d (e-PCR)
- UniSTS:324291

Y38F2A_6126.e (e-PCR)
- UniSTS:324292

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in post-translational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Sec61 translocon complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Sec61 translocon complex	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein transport protein Sec61 subunit beta

NP_500197.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

2388185..2388675 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067796.9 → NP_500197.1 Protein transport protein Sec61 subunit beta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500197.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95XS2

Conserved Domains (1) summary

pfam03911
Location:36 → 73

Sec61_beta; Sec61beta family