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    npl-4.2 Nuclear protein localization protein 4 homolog 2 [ Caenorhabditis elegans ]

    Gene ID: 3565577, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npl-4.2
    Official Full Name
    Nuclear protein localization protein 4 homolog 2
    Primary source
    WormBase:WBGene00019121
    Locus tag
    CELE_F59E12.5
    See related
    AllianceGenome:WB:WBGene00019121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin binding activity and ubiquitin protein ligase binding activity. Involved in ERAD pathway and embryo development. Located in nucleus. Part of VCP-NPL4-UFD1 AAA ATPase complex. Orthologous to human NPLOC4 (NPL4 homolog, ubiquitin recognition factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npl-4.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (5622889..5624959)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Hydroxysteroid dehydrogenase-like protein 2 Neighboring gene Eukaryotic translation initiation factor 3 subunit L Neighboring gene Protein kinase domain-containing protein Neighboring gene pseudo Neighboring gene ubiquitinyl hydrolase 1 Neighboring gene Nuclear protein localization protein 4 homolog 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Measuring and modelling mixture toxicity of imidacloprid and thiacloprid on Caenorhabditis elegans and Eisenia fetida. Gomez-Eyles JL, et al. Ecotoxicol Environ Saf, 2009 Jan. PMID 18723220
    2. Mechanisms of eukaryotic replisome disassembly. Moreno SP, et al. Biochem Soc Trans, 2020 Jun 30. PMID 32490508, Free PMC Article
    3. A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation. Mouysset J, et al. J Struct Biol, 2006 Oct. PMID 16647269
    4. Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Mouysset J, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18728180, Free PMC Article
    5. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Franz A, et al. Mol Cell, 2011 Oct 7. PMID 21981920, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of VCP-NPL4-UFD1 AAA ATPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear protein localization protein 4 homolog 2
    NP_001370454.1
    • Confirmed by transcript evidence
    NP_495093.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5622889..5624959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062692.5 → NP_495093.1  Nuclear protein localization protein 4 homolog 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495093.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01894, Q95QZ9
      Conserved Domains (4) summary
      smart00547
      Location:504 → 526
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:504 → 523
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam05020
      Location:13 → 148
      zf-NPL4; NPL4 family, putative zinc binding region
      pfam05021
      Location:151 → 470
      NPL4; NPL4 family

    2. NM_001383842.1 → NP_001370454.1  Nuclear protein localization protein 4 homolog 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (4) summary
      smart00547
      Location:502 → 524
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:502 → 521
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam05020
      Location:13 → 148
      zf-NPL4; NPL4 family, putative zinc binding region
      pfam05021
      Location:151 → 470
      NPL4; NPL4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95QZ9.1

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