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    aka-1 FYVE-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174216, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aka-1
    Official Full Name
    FYVE-type domain-containing protein
    Primary source
    WormBase:WBGene00000101
    Locus tag
    CELE_D1022.7
    See related
    AllianceGenome:WB:WBGene00000101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in endosomal transport. Predicted to be active in early endosome membrane. Orthologous to several human genes including ZFYVE9 (zinc finger FYVE-type containing 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aka-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    17
    Sequence:
    Chromosome: II; NC_003280.10 (7472729..7478537, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene E2 ubiquitin-conjugating enzyme Neighboring gene Putative carbonic anhydrase-like protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of structural features that mediate the tethering of Caenorhabditis elegans protein kinase A to a novel A kinase anchor protein. Insights into the anchoring of PKAI isoforms. Angelo RG, et al. J Biol Chem, 2000 Feb 11. PMID 10660605
    2. Structural diversity of the cAMP-dependent protein kinase regulatory subunit in Caenorhabditis elegans. Pastok MW, et al. Cell Signal, 2013 Jan. PMID 22975687
    3. Molecular characterization of an anchor protein (AKAPCE) that binds the RI subunit (RCE) of type I protein kinase A from Caenorhabditis elegans. Angelo R, et al. J Biol Chem, 1998 Jun 5. PMID 9603981
    4. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Hayakawa A, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16873553, Free PMC Article
    5. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FYVE-type domain-containing protein
    NP_001022045.1
    • Confirmed by transcript evidence
    NP_001379841.1
    • Confirmed by transcript evidence
    NP_495565.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7472729..7478537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063164.9 → NP_495565.2  FYVE-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495565.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZI9
      Conserved Domains (3) summary
      PTZ00341
      Location:334 → 477
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd15729
      Location:532 → 604
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11979
      Location:905 → 1257
      DUF3480; Domain of unknown function (DUF3480)

    2. NM_001026874.5 → NP_001022045.1  FYVE-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022045.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18930
      Conserved Domains (3) summary
      PTZ00341
      Location:334 → 477
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd15729
      Location:532 → 600
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11979
      Location:901 → 1253
      DUF3480; Domain of unknown function (DUF3480)

    3. NM_001393118.1 → NP_001379841.1  FYVE-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQ92
      Conserved Domains (2) summary
      PTZ00341
      Location:349 → 477
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd15729
      Location:532 → 586
      FYVE_endofin; FYVE domain found in endofin and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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