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    cec-6 Chromo domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177338, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cec-6
    Official Full Name
    Chromo domain-containing protein
    Primary source
    WormBase:WBGene00020463
    Locus tag
    CELE_T12E12.2
    See related
    AllianceGenome:WB:WBGene00020463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in heterochromatin formation. Predicted to be located in pericentric heterochromatin. Is expressed in germ line and germline precursor cell. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX6 (chromobox 6); CBX7 (chromobox 7); and CBX8 (chromobox 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cec-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (5544860..5548459)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Dynamin-1-like protein drp-1 Neighboring gene SPK domain-containing protein Neighboring gene putative E3 ubiquitin-protein ligase ariadne-2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in Caenorhabditis elegans. Saltzman AL, et al. Genetics, 2018 Nov. PMID 30185429, Free PMC Article
    2. Efficient target-selected mutagenesis in Caenorhabditis elegans: toward a knockout for every gene. Cuppen E, et al. Genome Res, 2007 May. PMID 17416746, Free PMC Article
    3. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    4. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pericentric heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Chromo domain-containing protein
    NP_500828.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5544860..5548459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068427.8 → NP_500828.1  Chromo domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500828.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22430
    Nucleotide Protein
    Heading Accession and Version

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