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    vps-2 Charged multivesicular body protein 2a [ Caenorhabditis elegans ]

    Gene ID: 174908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vps-2
    Official Full Name
    Charged multivesicular body protein 2a
    Primary source
    WormBase:WBGene00012903
    Locus tag
    CELE_Y46G5A.12
    See related
    AllianceGenome:WB:WBGene00012903
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport; and protein transport. Located in cytoplasm. Is expressed in several structures, including body wall musculature; intestine; non-striated muscle; pharynx; and tail. Orthologous to human CHMP2A (charged multivesicular body protein 2A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vps-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (12767221..12768217, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Calcineurin-interacting protein 2 Neighboring gene RRM domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical Approaches to Studying Caenorhabditis elegans ESCRT Functions In Vitro. Block S, et al. Methods Mol Biol, 2019. PMID 31250303, Free PMC Article
    2. Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos. Frankel EB, et al. Nat Commun, 2017 Nov 13. PMID 29129923, Free PMC Article
    3. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endosome transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Charged multivesicular body protein 2a
    NP_496717.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12767221..12768217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064316.7 → NP_496717.1  Charged multivesicular body protein 2a [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496717.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2F6
      Conserved Domains (1) summary
      pfam03357
      Location:17 → 186
      Snf7; Snf7
    Nucleotide Protein
    Heading Accession and Version

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