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    ark-1 Ack-related non-receptor tyrosine kinase [ Caenorhabditis elegans ]

    Gene ID: 178218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ark-1
    Official Full Name
    Ack-related non-receptor tyrosine kinase
    Primary source
    WormBase:WBGene00000186
    Locus tag
    CELE_C01C7.1
    See related
    AllianceGenome:WB:WBGene00000186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine kinase activity. Involved in embryo development; negative regulation of epidermal growth factor receptor signaling pathway; and negative regulation of vulval development. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ark-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (12622091..12631022, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene G-patch domain-containing protein Neighboring gene Exchange factor for Arf-6 Neighboring gene Transcriptional regulator Neighboring gene V-type proton ATPase 116 kDa subunit a 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved tyrosine kinase promotes the import of silencing RNA into Caenorhabditis elegans cells. Jose AM, et al. Proc Natl Acad Sci U S A, 2012 Sep 4. PMID 22912399, Free PMC Article
    2. Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation. Yoon CH, et al. Mol Biol Cell, 2000 Nov. PMID 11071924, Free PMC Article
    3. Developmental biology. A pattern of precision. Sternberg PW. Science, 2004 Jan 30. PMID 14752152
    4. Cryptic quantitative evolution of the vulva intercellular signaling network in Caenorhabditis. Félix MA. Curr Biol, 2007 Jan 23. PMID 17240335
    5. Positive versus negative signaling of LET-23: regulation through the adaptor protein, SEM-5. Worby C, et al. Sci STKE, 2000 Dec 19. PMID 11752629

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ack-related non-receptor tyrosine kinase
    NP_001255653.1
    • Confirmed by transcript evidence
    NP_001255654.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12622091..12631022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268725.4 → NP_001255654.1  Ack-related non-receptor tyrosine kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255654.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6KRP0, G5EBZ8
      Conserved Domains (4) summary
      smart00219
      Location:113 → 376
      TyrKc; Tyrosine kinase, catalytic domain
      smart00326
      Location:384 → 434
      SH3; Src homology 3 domains
      cd05040
      Location:117 → 378
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      cl15755
      Location:14 → 71
      SAM_superfamily; SAM (Sterile alpha motif )

    2. NM_001268724.2 → NP_001255653.1  Ack-related non-receptor tyrosine kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255653.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBZ8
      Conserved Domains (4) summary
      smart00219
      Location:113 → 376
      TyrKc; Tyrosine kinase, catalytic domain
      smart00326
      Location:384 → 434
      SH3; Src homology 3 domains
      cd05040
      Location:117 → 378
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      cl15755
      Location:14 → 71
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EBZ8.1

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