dif-1 Protein dif-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dif-1
Official Full Name: Protein dif-1
Primary source: WormBase:WBGene00000996
Locus tag: CELE_F49E8.5
See related: AllianceGenome:WB:WBGene00000996
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable acyl carnitine transmembrane transporter activity. Involved in mitochondrial transport. Located in mitochondrial envelope. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in carnitine-acylcarnitine translocase deficiency. Orthologous to human SLC25A20 (solute carrier family 25 member 20). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dif-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (7551657..7552874, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F49E8.5 (e-PCR)
- UniSTS:311700

F49E8.6 (e-PCR)
- UniSTS:320982

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP:ADP antiporter activity	IEA Inferred from Electronic Annotation more info
enables acyl carnitine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in acyl carnitine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in carnitine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial ADP transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial ATP transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial envelope	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein dif-1

NP_001379917.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7551657..7552874 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392331.1 → NP_001379917.1 Protein dif-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20630, Q27257

Conserved Domains (1) summary

pfam00153
Location:100 → 198

Mito_carr; Mitochondrial carrier protein