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    catp-7 Cation-transporting ATPase [ Caenorhabditis elegans ]

    Gene ID: 177664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    catp-7
    Official Full Name
    Cation-transporting ATPase
    Primary source
    WormBase:WBGene00022010
    Locus tag
    CELE_Y59H11AR.2
    See related
    AllianceGenome:WB:WBGene00022010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity and polyamine transmembrane transporter activity. Predicted to be involved in intracellular calcium ion homeostasis and polyamine transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including excretory cell; gonad; spermatid; spermatocyte; and vulva. Human ortholog(s) of this gene implicated in Kufor-Rakeb syndrome; Parkinson's disease; hereditary spastic paraplegia 78; and primary pulmonary hypertension. Orthologous to several human genes including ATP13A3 (ATPase 13A3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See catp-7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    16
    Sequence:
    Chromosome: IV; NC_003282.8 (8585983..8594616)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Major sperm protein Neighboring gene ZP domain-containing protein Neighboring gene C-type lectin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overlapping expression patterns and functions of three paralogous P5B ATPases in Caenorhabditis elegans. Zielich J, et al. PLoS One, 2018. PMID 29547664, Free PMC Article
    2. ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress. Vrijsen S, et al. Proc Natl Acad Sci U S A, 2020 Dec 8. PMID 33229544, Free PMC Article
    3. CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching. Feng Z, et al. Cell Rep, 2020 Sep 8. PMID 32905774
    4. The effects of plant cysteine proteinases on the nematode cuticle. Njom VS, et al. Parasit Vectors, 2021 Jun 5. PMID 34090505, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyamine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cation-transporting ATPase
    NP_001023543.1
    • Confirmed by transcript evidence
    NP_001367848.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8585983..8594616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380374.1 → NP_001367848.1  Cation-transporting ATPase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N323
      Conserved Domains (2) summary
      cd07542
      Location:189 → 1016
      P-type_ATPase_cation; P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p
      pfam12409
      Location:51 → 157
      P5-ATPase; P5-type ATPase cation transporter

    2. NM_001028372.5 → NP_001023543.1  Cation-transporting ATPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023543.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86FP2
      Conserved Domains (6) summary
      COG4087
      Location:803 → 847
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01657
      Location:33 → 1076
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:227 → 469
      E1-E2_ATPase; E1-E2 ATPase
      pfam00690
      Location:153 → 217
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12409
      Location:35 → 137
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:583 → 625
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein
    Heading Accession and Version

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