U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cccp-1 CARD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176674, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cccp-1
    Official Full Name
    CARD domain-containing protein
    Primary source
    WormBase:WBGene00013042
    Locus tag
    CELE_Y49E10.23
    See related
    AllianceGenome:WB:WBGene00013042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables small GTPase binding activity. Involved in dense core granule maturation and regulation of locomotion involved in locomotory behavior. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in intestine; neurons; and spermatheca. Orthologous to human CCDC186 (coiled-coil domain containing 186). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cccp-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (12472873..12484651)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Phosphoryl Seryl-TRNA (Ser/Sec) Kinase Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Arrestin C-terminal-like domain-containing protein Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The dense-core vesicle maturation protein CCCP-1 binds RAB-2 and membranes through its C-terminal domain. Cattin-Ortolá J, et al. Traffic, 2017 Nov. PMID 28755404, Free PMC Article
    2. Two Rab2 interactors regulate dense-core vesicle maturation. Ailion M, et al. Neuron, 2014 Apr 2. PMID 24698274, Free PMC Article
    3. Genetic analysis of defecation in Caenorhabditis elegans. Thomas JH. Genetics, 1990 Apr. PMID 2323555, Free PMC Article
    4. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article
    5. Functional transcriptomics of a migrating cell in Caenorhabditis elegans. Schwarz EM, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22991463, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We conclude that CCCP-1 is a coiled-coil protein that binds an activated Rab and localizes to the Golgi via its C-terminus.
      Title: The dense-core vesicle maturation protein CCCP-1 binds RAB-2 and membranes through its C-terminal domain.
    2. This study demonistrated that cccp-1 regulate dense-core vesicle maturation.
      Title: Two Rab2 interactors regulate dense-core vesicle maturation.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dense core granule maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion involved in locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle cytoskeletal trafficking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    CARD domain-containing protein
    NP_499628.1
    • Confirmed by transcript evidence
    NP_871700.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12472873..12484651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_181971.6 → NP_871700.1  CARD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871700.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0Z1
      Conserved Domains (1) summary
      COG1196
      Location:159 → 507
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_067227.7 → NP_499628.1  CARD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499628.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XTT2
      Conserved Domains (1) summary
      COG1196
      Location:159 → 507
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools