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    npp-1 Nucleoporin Nup54 alpha-helical domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npp-1
    Official Full Name
    Nucleoporin Nup54 alpha-helical domain-containing protein
    Primary source
    WormBase:WBGene00003787
    Locus tag
    CELE_K07F5.13
    See related
    AllianceGenome:WB:WBGene00003787
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calmodulin binding activity. Involved in several processes, including establishment of mitotic spindle orientation; nuclear pore organization; and positive regulation of mitotic cell cycle, embryonic. Located in nuclear envelope. Is expressed in several structures, including hypodermis. Human ortholog(s) of this gene implicated in dystonia 37, early-onset with striatal lesions. Orthologous to human NUP54 (nucleoporin 54). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npp-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (9858488..9862119)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Sperm-Specific family, class Q Neighboring gene Transmembrane protein 144 homolog Neighboring gene NUC153 domain-containing protein Neighboring gene J domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans. Martino L, et al. Dev Cell, 2017 Oct 23. PMID 29065307, Free PMC Article
    2. Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans. Schetter A, et al. Dev Biol, 2006 Jan 15. PMID 16325795, Free PMC Article
    3. Sensitized piRNA reporter identifies multiple RNA processing factors involved in piRNA-mediated gene silencing. Brown JS, et al. Genetics, 2023 Aug 9. PMID 37210214, Free PMC Article
    4. Age-related changes of nuclear architecture in Caenorhabditis elegans. Haithcock E, et al. Proc Natl Acad Sci U S A, 2005 Nov 15. PMID 16269543, Free PMC Article
    5. Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos. Nkombo Nkoula S, et al. Sci Adv, 2023 Jul 21. PMID 37467327, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear pore organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle, embryonic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nucleoporin Nup54 alpha-helical domain-containing protein
    NP_001379121.1
    • Partially confirmed by transcript evidence
    NP_501770.1
    • Confirmed by transcript evidence
    NP_501771.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9858488..9862119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069369.5 → NP_501770.1  Nucleoporin Nup54 alpha-helical domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501770.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3B9
      Conserved Domains (3) summary
      pfam13634
      Location:2 → 106
      Nucleoporin_FG; Nucleoporin FG repeat region
      pfam13874
      Location:443 → 574
      Nup54; Nucleoporin complex subunit 54
      pfam15967
      Location:83 → 219
      Nucleoporin_FG2; Nucleoporin FG repeated region

    2. NM_069370.5 → NP_501771.1  Nucleoporin Nup54 alpha-helical domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501771.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3C1
      Conserved Domains (2) summary
      pfam13634
      Location:2 → 122
      Nucleoporin_FG; Nucleoporin FG repeat region
      pfam13874
      Location:353 → 484
      Nup54; Nucleoporin complex subunit 54

    3. NM_001392375.1 → NP_001379121.1  Nucleoporin Nup54 alpha-helical domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21295, Q21296
      Conserved Domains (3) summary
      pfam13634
      Location:49 → 132
      Nucleoporin_FG; Nucleoporin FG repeat region
      pfam13874
      Location:416 → 550
      Nup54; Nucleoporin complex subunit 54
      pfam15967
      Location:62 → 262
      Nucleoporin_FG2; Nucleoporin FG repeated region
    Nucleotide Protein
    Heading Accession and Version

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