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    ksr-1 Kinase suppressor of Ras A [ Caenorhabditis elegans ]

    Gene ID: 181082, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ksr-1
    Official Full Name
    Kinase suppressor of Ras A
    Primary source
    WormBase:WBGene00002239
    Locus tag
    CELE_F13B9.5
    See related
    AllianceGenome:WB:WBGene00002239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables mitogen-activated protein kinase kinase binding activity and protein kinase activity. Involved in several processes, including defense response to Gram-positive bacterium; positive regulation of Ras protein signal transduction; and positive regulation of vulval development. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to several human genes including KSR1 (kinase suppressor of ras 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ksr-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (8275169..8283301)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ZP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FIS1-related protein fis-2 Neighboring gene ncRNA Neighboring gene Ground-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of Gq-Rho Signaling by the ERK MAPK Pathway Controls Locomotion in Caenorhabditis elegans. Coleman B, et al. Genetics, 2018 Jun. PMID 29615470, Free PMC Article
    2. Regulation of response to nanopolystyrene by intestinal microRNA mir-35 in nematode Caenorhabditis elegans. Li D, et al. Sci Total Environ, 2020 Sep 20. PMID 32473456
    3. The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans. Masoudi N, et al. Development, 2013 Aug. PMID 23900546, Free PMC Article
    4. Nanoplastics cause transgenerational toxicity through inhibiting germline microRNA mir-38 in C. elegans. Hua X, et al. J Hazard Mater, 2022 Sep 5. PMID 35716568
    5. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Clapéron A, et al. Oncogene, 2007 May 14. PMID 17496912

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KSR-1 modulates locomotion downstream of, or in parallel to, the Gq-Rho pathway.
      Title: Modulation of Gq-Rho Signaling by the ERK MAPK Pathway Controls Locomotion in Caenorhabditis elegans.
    2. Review highlights the implication of CNK and KSR in a novel mechanism regulating RAS-mediated RAF activation.
      Title: KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myoblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kinase suppressor of Ras A
    NP_509396.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8275169..8283301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076995.7 → NP_509396.1  Kinase suppressor of Ras A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509396.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFD2
      Conserved Domains (3) summary
      cd00029
      Location:216 → 269
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam07714
      Location:474 → 741
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:482 → 751
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFD2.1

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