fbl-1 Fibulin-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fbl-1
Official Full Name: Fibulin-1
Primary source: WormBase:WBGene00001403
Locus tag: CELE_F56H11.1
See related: AllianceGenome:WB:WBGene00001403
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: An extracellular matrix structural constituent. Involved in extracellular matrix organization; positive regulation of locomotion; and protein localization. Located in basement membrane. Is expressed in several structures, including anal depressor muscle; basal lamina; intestine; nervous system; and reproductive system. Orthologous to several human genes including FBLN1 (fibulin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fbl-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 17

Sequence:: Chromosome: IV; NC_003282.8 (9540806..9546252)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in fibulin-1 and collagen IV suppress the short healthspan of mig-17/ADAMTS mutants in Caenorhabditis elegans.
Title: Mutations in fibulin-1 and collagen IV suppress the short healthspan of mig-17/ADAMTS mutants in Caenorhabditis elegans.
A series of deletion constructs shows that EGF repeats 4 and 5 are required for the hemicentin-dependent assembly and function of fibulin-1D in native locations.
Title: Distinct regions within fibulin-1D modulate interactions with hemicentin.
A dominant mutation in the EMB-9/type IV collagen alpha1 subunit can compensate for loss of FBL-1 activity in gonadogenesis.
Title: Tissue architecture in the Caenorhabditis elegans gonad depends on interactions among fibulin-1, type IV collagen and the ADAMTS extracellular protease.
There is a distinct developmental roles and hemicentin-dependent assembly for fibulin-1 splice variants
Title: Fibulin-1C and Fibulin-1D splice variants have distinct functions and assemble in a hemicentin-dependent manner.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56H11.1 (e-PCR)
- UniSTS:311884

T05A1.6 (e-PCR)
- UniSTS:316127

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptidase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Fibulin-1

NP_001023236.1

Confirmed by transcript evidence

NP_001023237.1

Confirmed by transcript evidence

NP_001293875.1

Confirmed by transcript evidence

NP_001293876.1

Confirmed by transcript evidence

NP_001293877.1

Confirmed by transcript evidence

NP_001293878.1

Confirmed by transcript evidence

NP_001293879.1

Confirmed by transcript evidence

NP_501694.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9540806..9546252

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069293.6 → NP_501694.2 Fibulin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501694.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O18026, O77469, O77474, Q20903, Q50JF9, Q5I5Q9, Q95NZ3, Q9TZS1

Conserved Domains (4) summary

smart00179
Location:343 → 380

EGF_CA; Calcium-binding EGF-like domain

pfam07645
Location:430 → 472

EGF_CA; Calcium-binding EGF domain

pfam12662
Location:540 → 563

cEGF; Complement Clr-like EGF-like

cl00057
Location:469 → 510

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001306949.2 → NP_001293878.1 Fibulin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293878.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061AIV4

Conserved Domains (4) summary

smart00179
Location:343 → 380

EGF_CA; Calcium-binding EGF-like domain

pfam07645
Location:430 → 472

EGF_CA; Calcium-binding EGF domain

pfam12662
Location:540 → 563

cEGF; Complement Clr-like EGF-like

cl00057
Location:469 → 510

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001028065.4 → NP_001023236.1 Fibulin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023236.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77469

Conserved Domains (4) summary

smart00179
Location:304 → 341

EGF_CA; Calcium-binding EGF-like domain

pfam07645
Location:391 → 433

EGF_CA; Calcium-binding EGF domain

pfam12662
Location:501 → 524

cEGF; Complement Clr-like EGF-like

cl00057
Location:430 → 471

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001028066.6 → NP_001023237.1 Fibulin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023237.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77469

Conserved Domains (4) summary

smart00179
Location:304 → 341

EGF_CA; Calcium-binding EGF-like domain

pfam07645
Location:391 → 433

EGF_CA; Calcium-binding EGF domain

pfam12662
Location:501 → 524

cEGF; Complement Clr-like EGF-like

cl00057
Location:430 → 471

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001306947.3 → NP_001293876.1 Fibulin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293876.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ADQ1

Conserved Domains (3) summary

smart00179
Location:343 → 380

EGF_CA; Calcium-binding EGF-like domain

pfam12662
Location:456 → 479

cEGF; Complement Clr-like EGF-like

cl00057
Location:386 → 426

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001306948.3 → NP_001293877.1 Fibulin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293877.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ACF5

Conserved Domains (3) summary

smart00179
Location:304 → 341

EGF_CA; Calcium-binding EGF-like domain

pfam12662
Location:417 → 440

cEGF; Complement Clr-like EGF-like

cl00057
Location:347 → 387

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001306950.3 → NP_001293879.1 Fibulin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293879.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061AKL1

Conserved Domains (3) summary

smart00179
Location:343 → 380

EGF_CA; Calcium-binding EGF-like domain

pfam12662
Location:456 → 479

cEGF; Complement Clr-like EGF-like

cl00057
Location:386 → 426

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001306946.3 → NP_001293875.1 Fibulin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293875.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ACI3

Conserved Domains (3) summary

smart00179
Location:304 → 341

EGF_CA; Calcium-binding EGF-like domain

pfam12662
Location:417 → 440

cEGF; Complement Clr-like EGF-like

cl00057
Location:347 → 387

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...