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    nhr-274 NR LBD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189825, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-274
    Official Full Name
    NR LBD domain-containing protein
    Primary source
    WormBase:WBGene00021522
    Locus tag
    CELE_Y41D4B.21
    See related
    AllianceGenome:WB:WBGene00021522
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-274 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (1637954..1645298, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Chondroitin sulfate proteoglycan 4 Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    2. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NR LBD domain-containing protein
    NP_001294522.1
    • Confirmed by transcript evidence
    NP_001368289.1
    • Confirmed by transcript evidence
    NP_001368290.1
    • Confirmed by transcript evidence
    NP_500114.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1637954..1645298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067713.5 → NP_500114.3  NR LBD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500114.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Y05
      Conserved Domains (2) summary
      cd06960
      Location:36 → 111
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:214 → 388
      HOLI; Ligand binding domain of hormone receptors

    2. NM_001380055.1 → NP_001368289.1  NR LBD domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEZ8
      Conserved Domains (1) summary
      smart00430
      Location:114 → 288
      HOLI; Ligand binding domain of hormone receptors

    3. NM_001380054.1 → NP_001368290.1  NR LBD domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBS1
      Conserved Domains (2) summary
      cd06960
      Location:36 → 111
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:214 → 388
      HOLI; Ligand binding domain of hormone receptors

    4. NM_001307593.4 → NP_001294522.1  NR LBD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294522.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PC44
      Conserved Domains (1) summary
      smart00430
      Location:114 → 288
      HOLI; Ligand binding domain of hormone receptors
    Nucleotide Protein
    Heading Accession and Version

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