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    hrpf-1 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hrpf-1
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00020936
    Locus tag
    CELE_W02D3.11
    See related
    AllianceGenome:WB:WBGene00020936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed widely. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hrpf-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (6753219..6756348, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Succinate dehydrogenase assembly factor 4, mitochondrial Neighboring gene Transcription factor unc-37 Neighboring gene FANCI helical domain-containing protein Neighboring gene ncRNA Neighboring gene G protein gamma domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing and the steady-state ratios of mRNA isoforms generated by it are under strong stabilizing selection in Caenorhabditis elegans. Barberan-Soler S, et al. Mol Biol Evol, 2008 Nov. PMID 18718918, Free PMC Article
    2. An autoregulation loop in fust-1 for circular RNA regulation in Caenorhabditis elegans. Cao D. Genetics, 2021 Nov 5. PMID 34740247, Free PMC Article
    3. Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy. Walsh MB, et al. BMC Biol, 2020 Sep 16. PMID 32938453, Free PMC Article
    4. Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. Barberan-Soler S, et al. PLoS Genet, 2008 Feb 29. PMID 18454200, Free PMC Article
    5. A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. Giles AC, et al. J Biol Chem, 2019 Apr 26. PMID 30858176, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_001359979.1
    • Confirmed by transcript evidence
    NP_740877.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6753219..6756348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001372997.1 → NP_001359979.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZN0
      Conserved Domains (3) summary
      COG0724
      Location:98 → 313
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12254
      Location:7 → 75
      RRM_hnRNPH_ESRPs_RBM12_like; RNA recognition motif found in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family, epithelial splicing regulatory proteins (ESRPs), Drosophila RNA-binding protein Fusilli, RNA-binding protein 12 (RBM12) and similar proteins
      cd12504
      Location:123 → 199
      RRM2_hnRNPH_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family

    2. NM_170888.7 → NP_740877.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740877.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BIB7
      Conserved Domains (3) summary
      COG0724
      Location:10 → 183
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12254
      Location:472 → 542
      RRM_hnRNPH_ESRPs_RBM12_like; RNA recognition motif found in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family, epithelial splicing regulatory proteins (ESRPs), Drosophila RNA-binding protein Fusilli, RNA-binding protein 12 (RBM12) and similar proteins
      cl17169
      Location:123 → 199
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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