gcy-28 Receptor-type guanylate cyclase gcy-28 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gcy-28
Official Full Name: Receptor-type guanylate cyclase gcy-28
Primary source: WormBase:WBGene00020131
Locus tag: CELE_T01A4.1
See related: AllianceGenome:WB:WBGene00020131
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables guanylate cyclase activity. Involved in several processes, including olfactory behavior; sensory perception of chemical stimulus; and sensory processing. Located in cell body and neuron projection. Is expressed in several structures, including body wall musculature; hypodermis; intestine; neurons; and reproductive system. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; essential hypertension; and myocardial infarction. Orthologous to several human genes including NPR1 (natriuretic peptide receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gcy-28 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 23

Sequence:: Chromosome: I; NC_003279.8 (4481198..4508940)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

reveal a novel role of GCY-28 in the retrieval of associative memories and may have wide implications for the neural machineries of learning and memory in general
Title: Mutations in the guanylate cyclase gcy-28 neuronally dissociate naïve attraction and memory retrieval.
GCY-28 and SCD-2 regulate sensory integration by modulating the activity of interneurons. Proper sensory integration is important for proper behavioral choices.
Title: Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans.
Mutations in the receptor-type guanylate cyclase gcy-28 lead to an avoidance behavior in place of the attractive behavior normally directed by the olfactory AWC(ON) neuron.
Title: A behavioral switch: cGMP and PKC signaling in olfactory neurons reverses odor preference in C. elegans.

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Pathways from PubChem

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General gene information

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Markers

T01A4.1 (e-PCR)
- UniSTS:317407

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of chemical stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory perception of chemical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Receptor-type guanylate cyclase gcy-28

NP_001021600.1

Confirmed by transcript evidence

NP_001249628.1

Confirmed by transcript evidence

NP_001360115.1

Confirmed by transcript evidence

NP_001380039.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4481198..4508940

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001262699.2 → NP_001249628.1 Receptor-type guanylate cyclase gcy-28 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001249628.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q86GV3

Conserved Domains (7) summary

cd06373
Location:45 → 460

PBP1_NPR_like; Ligand binding domain of natriuretic peptide receptor (NPR) family

smart00044
Location:1012 → 1195

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

smart00221
Location:703 → 970

STYKc; Protein kinase; unclassified specificity

cd14042
Location:684 → 978

PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

pfam00211
Location:1039 → 1224

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:74 → 439

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:988 → 1033

HNOBA; Heme NO binding associated
NM_001026429.3 → NP_001021600.1 Receptor-type guanylate cyclase gcy-28 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021600.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L0J9, Q86GV3, Q965F7, Q965F8

UniProtKB/TrEMBL

Q8T8L6

Conserved Domains (7) summary

cd06373
Location:42 → 486

PBP1_NPR_like; Ligand binding domain of natriuretic peptide receptor (NPR) family

smart00044
Location:1050 → 1233

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

smart00221
Location:741 → 1008

STYKc; Protein kinase; unclassified specificity

cd14042
Location:722 → 1016

PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

pfam00211
Location:1077 → 1262

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:64 → 465

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:1026 → 1071

HNOBA; Heme NO binding associated
NM_001392156.1 → NP_001380039.1 Receptor-type guanylate cyclase gcy-28 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (4) summary

smart00044
Location:991 → 1174

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14042
Location:663 → 957

PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

cd06373
Location:30 → 438

PBP1_NPR-like; Ligand binding domain of natriuretic peptide receptor (NPR) family

pfam07701
Location:964 → 1012

HNOBA; Heme NO binding associated
NM_001372632.3 → NP_001360115.1 Receptor-type guanylate cyclase gcy-28 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

smart00044
Location:423 → 591

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14042
Location:95 → 389

PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

pfam07701
Location:396 → 444

HNOBA; Heme NO binding associated