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    crn-2 Deoxyribonuclease TATDN1 [ Caenorhabditis elegans ]

    Gene ID: 178945, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crn-2
    Official Full Name
    Deoxyribonuclease TATDN1
    Primary source
    WormBase:WBGene00000795
    Locus tag
    CELE_CD4.2
    See related
    AllianceGenome:WB:WBGene00000795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA nuclease activity. Involved in apoptotic DNA fragmentation and apoptotic cell clearance. Predicted to be active in cytosol. Is expressed in head; intestine; and tail. Orthologous to human TATDN1 (TatD DNase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See crn-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (5594615..5595842)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene VPS37 C-terminal domain-containing protein Neighboring gene Small ribosomal subunit protein uS10 domain-containing protein Neighboring gene HIT-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SPK domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Nakagawa A, et al. Science, 2010 Apr 16. PMID 20223951, Free PMC Article
    2. DNase II: genes, enzymes and function. Evans CJ, et al. Gene, 2003 Dec 11. PMID 14644493
    3. Functional genomic analysis of apoptotic DNA degradation in C. elegans. Parrish JZ, et al. Mol Cell, 2003 Apr. PMID 12718884
    4. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Boyd WA, et al. Mutat Res, 2010 Jan 5. PMID 19879883, Free PMC Article
    5. Programmed cell death. Conradt B, et al. WormBook, 2005 Oct 6. PMID 18061982, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic DNA fragmentation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response HEP PubMed 

    General protein information

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    Preferred Names
    Deoxyribonuclease TATDN1
    NP_504476.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5594615..5595842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072075.8 → NP_504476.1  Deoxyribonuclease TATDN1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504476.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG18
      Conserved Domains (2) summary
      cd01310
      Location:6 → 284
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
      pfam00702
      Location:21 → 96
      Hydrolase; haloacid dehalogenase-like hydrolase
    Nucleotide Protein
    Heading Accession and Version

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