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    vacl-14 Protein VAC14 homolog [ Caenorhabditis elegans ]

    Gene ID: 172589, updated on 9-Dec-2024

    Summary

    Official Symbol
    vacl-14
    Official Full Name
    Protein VAC14 homolog
    Primary source
    WormBase:WBGene00010565
    Locus tag
    CELE_K04G2.6
    See related
    AllianceGenome:WB:WBGene00010565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in phosphatidylinositol biosynthetic process. Predicted to be located in membrane. Predicted to be part of PAS complex. Predicted to be active in endosome membrane. Human ortholog(s) of this gene implicated in striatonigral degeneration. Orthologous to human VAC14 (VAC14 component of PIKFYVE complex). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See vacl-14 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (8040799..8043278)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene SHSP domain-containing protein Neighboring gene palmitoyl-protein hydrolase Neighboring gene Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein Neighboring gene CASP-like protein Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of PAS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of PAS complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Protein VAC14 homolog
    NP_492215.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8040799..8043278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059814.5NP_492215.1  Protein VAC14 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492215.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21225
      Conserved Domains (3) summary
      pfam11916
      Location:457631
      Vac14_Fig4_bd; Vacuolar protein 14 C-terminal Fig4p binding
      pfam12755
      Location:65162
      Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
      sd00044
      Location:93121
      HEAT; HEAT repeat [structural motif]