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    dsb-1 Double-Strand Break factor [ Caenorhabditis elegans ]

    Gene ID: 178192, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dsb-1
    Official Full Name
    Double-Strand Break factor
    Primary source
    WormBase:WBGene00008580
    Locus tag
    CELE_F08G5.1
    See related
    AllianceGenome:WB:WBGene00008580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in condensed chromosome. Is expressed in gonad. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dsb-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (12408925..12410470)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Membrane-associated protein gex-3 Neighboring gene Acyltransferase C-terminal domain-containing protein;Phospholipid/glycerol acyltransferase domain-containing protein Neighboring gene BMERB domain-containing protein;Mnd1 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of DSB-1, a protein required for initiation of meiotic recombination in Caenorhabditis elegans, illuminates a crossover assurance checkpoint. Stamper EL, et al. PLoS Genet, 2013. PMID 23990794, Free PMC Article
    2. Caenorhabditis elegans DSB-3 reveals conservation and divergence among protein complexes promoting meiotic double-strand breaks. Hinman AW, et al. Proc Natl Acad Sci U S A, 2021 Aug 17. PMID 34389685, Free PMC Article
    3. Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity. Guo H, et al. Elife, 2022 Jun 27. PMID 35758641, Free PMC Article
    4. Chromatin landscape, DSB levels, and cKU-70/80 contribute to patterning of meiotic DSB processing along chromosomes in C. elegans. Lascarez-Lagunas LI, et al. PLoS Genet, 2023 Jan. PMID 36706157, Free PMC Article
    5. PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis. Trivedi S, et al. Nucleic Acids Res, 2022 Nov 28. PMID 36478097, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Double-Strand Break factor
    NP_001255642.1
    • Product from WormBase gene class dsb;
      Confirmed by transcript evidence
    NP_001255643.1
    • Product from WormBase gene class dsb;
      Confirmed by transcript evidence
    NP_001293955.1
    • Product from WormBase gene class dsb;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12408925..12410470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268713.2 → NP_001255642.1  Double-Strand Break factor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255642.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19220

    2. NM_001268714.3 → NP_001255643.1  Double-Strand Break factor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255643.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D4PH99

    3. NM_001307026.4 → NP_001293955.1  Double-Strand Break factor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293955.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ADZ9
    Nucleotide Protein
    Heading Accession and Version

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