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    qns-1 Glutamine-dependent NAD(+) synthetase;NAD/GMP synthase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177900, updated on 9-Dec-2024

    Summary

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    Official Symbol
    qns-1
    Official Full Name
    Glutamine-dependent NAD(+) synthetase;NAD/GMP synthase domain-containing protein
    Primary source
    WormBase:WBGene00007698
    Locus tag
    CELE_C24F3.4
    See related
    AllianceGenome:WB:WBGene00007698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables NAD+ synthase activity. Involved in NAD biosynthetic process and determination of adult lifespan. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human NADSYN1 (NAD synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See qns-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (10214986..10219308, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Serpentine receptor class gamma Neighboring gene ABC transporter domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Translocating chain-associated membrane protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Mouchiroud L, et al. Cell, 2013 Jul 18. PMID 23870130, Free PMC Article
    2. Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Yang W, et al. Aging Cell, 2010 Jun. PMID 20346072
    3. Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor. Bar DZ, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27457958, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Glutamine-dependent NAD(+) synthetase;NAD/GMP synthase domain-containing protein
    NP_001255472.1
    • Confirmed by transcript evidence
    NP_001255473.1
    • Confirmed by transcript evidence
    NP_001255474.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10214986..10219308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268543.4 → NP_001255472.1  Glutamine-dependent NAD(+) synthetase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255472.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XXK6
      Conserved Domains (3) summary
      cd07570
      Location:9 → 298
      GAT_Gln-NAD-synth; Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases)
      PLN02339
      Location:6 → 702
      PLN02339; NAD+ synthase (glutamine-hydrolysing)
      cd00553
      Location:334 → 654
      NAD_synthase; NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD ...

    2. NM_001268544.3 → NP_001255473.1  Glutamine-dependent NAD(+) synthetase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255473.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3Y5P6
      Conserved Domains (2) summary
      cd07570
      Location:2 → 227
      GAT_Gln-NAD-synth; Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases)
      cd00553
      Location:263 → 583
      NAD_synthase; NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD ...

    3. NM_001268545.3 → NP_001255474.1  NAD/GMP synthase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255474.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3Y5P7
      Conserved Domains (1) summary
      PLN02339
      Location:1 → 278
      PLN02339; NAD+ synthase (glutamine-hydrolysing)
    Nucleotide Protein
    Heading Accession and Version

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