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    che-12 Crescerin-like protein che-12 [ Caenorhabditis elegans ]

    Gene ID: 179433, updated on 9-Dec-2024

    Summary

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    Official Symbol
    che-12
    Official Full Name
    Crescerin-like protein che-12
    Primary source
    WormBase:WBGene00000491
    Locus tag
    CELE_B0024.8
    See related
    AllianceGenome:WB:WBGene00000491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable microtubule binding activity. Involved in several processes, including chemotaxis; cilium assembly; and hyperosmotic response. Located in cilium; dendrite; and neuronal cell body. Is expressed in amphid neurons and phasmid neurons. Used to study ciliopathy. Human ortholog(s) of this gene implicated in Joubert syndrome. Orthologous to human TOGARAM1 (TOG array regulator of axonemal microtubules 1) and TOGARAM2 (TOG array regulator of axonemal microtubules 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See che-12 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    25
    Sequence:
    Chromosome: V; NC_003283.11 (10299472..10307383, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CUB_2 domain-containing protein Neighboring gene ncRNA Neighboring gene Receptor-type guanylate cyclase gcy-6 Neighboring gene Thioredoxin;putative thioredoxin-2 Neighboring gene TUG ubiquitin-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biallelic mutations in the TOGARAM1 gene cause a novel primary ciliopathy. Morbidoni V, et al. J Med Genet, 2021 Aug. PMID 32747439
    2. Crescerin uses a TOG domain array to regulate microtubules in the primary cilium. Das A, et al. Mol Biol Cell, 2015 Nov 15. PMID 26378256, Free PMC Article
    3. A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans. Neal SJ, et al. G3 (Bethesda), 2016 May 3. PMID 26976437, Free PMC Article
    4. A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. Kaplan JM, et al. Proc Natl Acad Sci U S A, 1993 Mar 15. PMID 8460126, Free PMC Article
    5. The conserved proteins CHE-12 and DYF-11 are required for sensory cilium function in Caenorhabditis elegans. Bacaj T, et al. Genetics, 2008 Feb. PMID 18245347, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Crescerin-like protein che-12
    NP_001256204.1
    • Confirmed by transcript evidence
    NP_001256205.1
    • Confirmed by transcript evidence
    NP_001256206.1
    • Confirmed by transcript evidence
    NP_001294732.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10299472..10307383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269275.3 → NP_001256204.1  Crescerin-like protein che-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256204.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E9P869, E9P870, M1ZMI6, Q17423

    2. NM_001269276.3 → NP_001256205.1  Crescerin-like protein che-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256205.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17423

    3. NM_001307803.4 → NP_001294732.1  Crescerin-like protein che-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294732.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17423

    4. NM_001269277.3 → NP_001256206.1  Crescerin-like protein che-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17423
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17423.3

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