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    immt-2 MICOS complex subunit MIC60-2 [ Caenorhabditis elegans ]

    Gene ID: 180122, updated on 9-Dec-2024

    Summary

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    Official Symbol
    immt-2
    Official Full Name
    MICOS complex subunit MIC60-2
    Primary source
    WormBase:WBGene00012315
    Locus tag
    CELE_W06H3.1
    See related
    AllianceGenome:WB:WBGene00012315
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in cristae formation and response to reactive oxygen species. Located in mitochondrial inner membrane. Part of proton-transporting ATP synthase complex. Orthologous to human IMMT (inner membrane mitochondrial protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See immt-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (16789267..16792773)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase dkf-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Pseudouridine synthase I TruA alpha/beta domain-containing protein;tRNA pseudouridine synthase Neighboring gene CTP synthase Neighboring gene Cullin-associated NEDD8-dissociated protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans. Wu X, et al. NPJ Aging, 2023 Aug 1. PMID 37528117, Free PMC Article
    2. Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology. Mun JY, et al. J Cell Physiol, 2010 Sep. PMID 20578245
    3. A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. Head BP, et al. Mol Biol Cell, 2011 Mar 15. PMID 21248201, Free PMC Article
    4. Novel putative interactors of FZO-1/mitofusin 2 identified using large-scale yeast two-hybrid screening in C. elegans. Dhananjay S, et al. MicroPubl Biol, 2022. PMID 36530473, Free PMC Article
    5. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Berends CW, et al. Mol Biol Cell, 2013 Jul. PMID 23699393, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that the two C. elegans mitofilin isoforms, immt-1 and -2, have non-overlapping functions in controlling mitochondrial cristae formation.
      Title: Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MICOS complex subunit MIC60-2
    NP_507241.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16789267..16792773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074840.7 → NP_507241.2  MICOS complex subunit MIC60-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507241.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XXN2
      Conserved Domains (1) summary
      pfam09731
      Location:44 → 633
      Mitofilin; Mitochondrial inner membrane protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XXN2.2

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