ddi-1 Protein DDI1 homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ddi-1
Official Full Name: Protein DDI1 homolog 1
Primary source: WormBase:WBGene00015308
Locus tag: CELE_C01G5.6
See related: AllianceGenome:WB:WBGene00015308
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable aspartic-type endopeptidase activity. Involved in negative regulation of synapse assembly. Located in cytoplasm and nucleus. Is expressed widely. Orthologous to human DDI1 (DNA damage inducible 1 homolog 1) and DDI2 (DNA damage inducible 1 homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ddi-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (6522867..6524571)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DDI-1 expression is induced by proteasome dysfunction, and the authors show that DDI-1 is required to cleave and activate an endoplasmic reticulum-associated isoform of SKN-1.
Title: Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C01G5.6 (e-PCR)
- UniSTS:308875

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein DDI1 homolog 1

NP_500992.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6522867..6524571

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068591.5 → NP_500992.1 Protein DDI1 homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500992.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17569

Conserved Domains (1) summary

pfam09668
Location:221 → 345

Asp_protease; Aspartyl protease