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    mocs-1 Molybdenum cofactor sulfurase [ Caenorhabditis elegans ]

    Gene ID: 187534, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mocs-1
    Official Full Name
    Molybdenum cofactor sulfurase
    Primary source
    WormBase:WBGene00010983
    Locus tag
    CELE_R03A10.3
    See related
    AllianceGenome:WB:WBGene00010983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable molybdenum cofactor sulfurtransferase activity. Predicted to be involved in molybdopterin cofactor metabolic process. Is expressed in amphid sheath cell; head; intestine; and socket cell. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in xanthinuria type II. Orthologous to human MOCOS (molybdenum cofactor sulfurase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mocs-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (15435665..15440794, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FMRF-Like Peptide Neighboring gene kynurenine--oxoglutarate transaminase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders. Féron F, et al. Mol Psychiatry, 2016 Sep. PMID 26239292, Free PMC Article
    2. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum cofactor sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdenum cofactor sulfurtransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum cofactor sulfurtransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in molybdopterin cofactor metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molybdopterin cofactor metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Molybdenum cofactor sulfurase
    NP_510552.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15435665..15440794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078151.5 → NP_510552.2  Molybdenum cofactor sulfurase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510552.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21657
      Conserved Domains (4) summary
      PLN02724
      Location:3 → 705
      PLN02724; Molybdenum cofactor sulfurase
      pfam03473
      Location:579 → 688
      MOSC; MOSC domain
      pfam03476
      Location:452 → 569
      MOSC_N; MOSC N-terminal beta barrel domain
      cl18945
      Location:3 → 424
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21657.2

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