rmh-1 RecQ-mediated genome instability protein 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rmh-1
Official Full Name: RecQ-mediated genome instability protein 1 homolog
Primary source: WormBase:WBGene00019712
Locus tag: CELE_M01E11.3
See related: AllianceGenome:WB:WBGene00019712
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA binding activity. Involved in several processes, including DNA recombination; positive regulation of brood size; and positive regulation of reciprocal meiotic recombination. Located in chromosome and nucleoplasm. Orthologous to human RMI1 (RecQ mediated genome instability 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rmh-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (5573214..5576749)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline.
Title: The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline.
RMH-1 functions during meiosis to promote both crossover and non-crossover homologous recombination at appropriate chromosomal sites
Title: Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M01E11.3 (e-PCR)
- UniSTS:311952

M01E11.5 (e-PCR)
- UniSTS:311954

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in chiasma assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of brood size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in resolution of meiotic recombination intermediates	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RecQ family helicase-topoisomerase III complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nuclear body	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RecQ-mediated genome instability protein 1 homolog

NP_491632.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5573214..5576749

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059231.9 → NP_491632.1 RecQ-mediated genome instability protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491632.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91399

Conserved Domains (1) summary

pfam08585
Location:13 → 223

RMI1_N; RecQ mediated genome instability protein