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    usp-3 Ubiquitin carboxyl-terminal hydrolase [ Caenorhabditis elegans ]

    Gene ID: 190579, updated on 9-Dec-2024

    Summary

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    Official Symbol
    usp-3
    Official Full Name
    Ubiquitin carboxyl-terminal hydrolase
    Primary source
    WormBase:WBGene00013506
    Locus tag
    CELE_Y71A12B.9
    See related
    AllianceGenome:WB:WBGene00013506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type deubiquitinase activity and zinc ion binding activity. Predicted to be involved in protein deubiquitination and proteolysis. Predicted to be active in cytoplasm. Orthologous to human USP3 (ubiquitin specific peptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See usp-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (13942544..13951630, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Histone H2A/H2B/H3 domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein eS6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    2. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin carboxyl-terminal hydrolase
    NP_493434.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13942544..13951630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061033.5 → NP_493434.3  Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493434.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GRV2
      Conserved Domains (2) summary
      pfam00443
      Location:229 → 542
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:53 → 111
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    Nucleotide Protein
    Heading Accession and Version

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