unc-64 Syntaxin-1A homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-64
Official Full Name: Syntaxin-1A homolog
Primary source: WormBase:WBGene00006798
Locus tag: CELE_F56A8.7
See related: AllianceGenome:WB:WBGene00006798
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein-folding chaperone binding activity. Involved in several processes, including chemical synaptic transmission; insulin receptor signaling pathway; and positive regulation of anterior/posterior axon guidance. Located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Is expressed in several structures, including excretory gland cell; hermaphrodite gonad; intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Hirschsprung's disease; congenital diarrhea; and generalized epilepsy with febrile seizures plus 9. Orthologous to several human genes including STX1A (syntaxin 1A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-64 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (13277259..13283887)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans.
Title: Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans.
The plasma membrane-associated SNAREs syntaxin/unc-64 and SNAP-25/ric-4 function in parallel in regulating fat storage in C. elegans and regulate fat storage.
Title: UNC-64 and RIC-4, the plasma membrane-associated SNAREs syntaxin and SNAP-25, regulate fat storage in nematode Caenorhabditis elegans.
Results support a model for docking in which UNC-13 converts syntaxin from the closed to the open state, and open syntaxin acts directly in docking vesicles to the plasma membrane.
Title: Open syntaxin docks synaptic vesicles.
The UNC-13/Syntaxin interaction is required for nerve-evoked vesicle fusion and synaptic transmission.
Title: UNC-13 interaction with syntaxin is required for synaptic transmission.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56A8.7 (e-PCR)
- UniSTS:322180

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cuticle	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of anterior/posterior axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Syntaxin-1A homolog

NP_001022614.1

Confirmed by transcript evidence

NP_001366988.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

13277259..13283887

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001379980.1 → NP_001366988.1 Syntaxin-1A homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O16000, O18657, O61526, Q9TZZ0

Conserved Domains (2) summary

pfam00804
Location:32 → 228

Syntaxin

pfam05739
Location:229 → 277

SNARE; SNARE domain
NM_001027443.6 → NP_001022614.1 Syntaxin-1A homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022614.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O16000

Conserved Domains (3) summary

cd00179
Location:32 → 182

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cd15880
Location:192 → 260

SNARE_syntaxin1; SNARE motif of syntaxin 1

pfam00804
Location:32 → 228

Syntaxin; Syntaxin