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    spe-15 Myosin VI cargo binding domain-containing protein;Myosin motor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171712, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spe-15
    Official Full Name
    Myosin VI cargo binding domain-containing protein;Myosin motor domain-containing protein
    Primary source
    WormBase:WBGene00004969
    Locus tag
    CELE_F47G6.4
    See related
    AllianceGenome:WB:WBGene00004969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Involved in organelle localization and spermatid development. Predicted to be located in myofibril. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; endocytic vesicle; and plasma membrane. Is expressed in primary spermatocyte. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spe-15 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    18
    Sequence:
    Chromosome: I; NC_003279.8 (1446497..1465358)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative signal recognition particle 19 kDa protein Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene Glutathione S-transferase Neighboring gene LEM domain-containing protein Neighboring gene AMP-dependent synthetase/ligase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myosin VI is required for asymmetric segregation of cellular components during C. elegans spermatogenesis. Kelleher JF, et al. Curr Biol, 2000 Nov 30. PMID 11114515
    2. Effects of Microcystin-LR Exposure on Spermiogenesis in Nematode Caenorhabditis elegans. Li Y, et al. Int J Mol Sci, 2015 Sep 22. PMID 26402677, Free PMC Article
    3. Distinct roles of two myosins in C. elegans spermatid differentiation. Hu J, et al. PLoS Biol, 2019 Apr. PMID 30990821, Free PMC Article
    4. A family of unconventional myosins from the nematode Caenorhabditis elegans. Baker JP, et al. J Mol Biol, 1997 Oct 3. PMID 9325109
    5. Unconventional Myosins from Caenorhabditis elegans as a Probe to Study Human Orthologues. Johnson CA, et al. Biomolecules, 2022 Dec 16. PMID 36551317, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in organelle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Myosin VI cargo binding domain-containing protein;Myosin motor domain-containing protein
    NP_001293430.1
    • Confirmed by transcript evidence
    NP_001293431.1
    • Confirmed by transcript evidence
    NP_490856.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1446497..1465358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058455.6 → NP_490856.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490856.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZI9
      Conserved Domains (5) summary
      smart00015
      Location:820 → 837
      IQ; Calmodulin-binding motif
      cd01382
      Location:78 → 761
      MYSc_Myo6; class VI myosin, motor domain
      pfam02736
      Location:12 → 49
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam05672
      Location:929 → 1000
      MAP7; MAP7 (E-MAP-115) family
      pfam16521
      Location:1123 → 1211
      Myosin-VI_CBD; Myosin VI cargo binding domain

    2. NM_001306501.3 → NP_001293430.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293430.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RY57
      Conserved Domains (3) summary
      COG5022
      Location:2 → 328
      COG5022; Myosin heavy chain [General function prediction only]
      cl22853
      Location:1 → 84
      Motor_domain; Myosin and Kinesin motor domain
      pfam16521
      Location:446 → 534
      Myosin-VI_CBD; Myosin VI cargo binding domain

    3. NM_001306502.3 → NP_001293431.1  Myosin VI cargo binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293431.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RRZ0
      Conserved Domains (2) summary
      pfam07946
      Location:104 → 151
      DUF1682; Protein of unknown function (DUF1682)
      pfam16521
      Location:268 → 356
      Myosin-VI_CBD; Myosin VI cargo binding domain
    Nucleotide Protein
    Heading Accession and Version

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