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    crm-1 Cysteine-rich motor neuron 1 protein;Cysteine-rich motor neuron 1 protein-like [ Caenorhabditis elegans ]

    Gene ID: 179439, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crm-1
    Official Full Name
    Cysteine-rich motor neuron 1 protein;Cysteine-rich motor neuron 1 protein-like
    Primary source
    WormBase:WBGene00007103
    Locus tag
    CELE_B0024.14
    See related
    AllianceGenome:WB:WBGene00007103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. Is expressed in intestine; nervous system; pharynx; and reproductive system. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See crm-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    17
    Sequence:
    Chromosome: V; NC_003283.11 (10322283..10332112, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Putative pseudouridine synthase B0024.11 Neighboring gene Glucosamine 6-phosphate N-acetyltransferase Neighboring gene Polyprenal reductase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Actin-related protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of crm-1 in ionizing radiation-induced nervous system dysfunction in Caenorhabditis elegans. Long HQ, et al. Neural Regen Res, 2023 Jun. PMID 36453427, Free PMC Article
    2. Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus. Zhong Y, et al. Elife, 2017 May 2. PMID 28463106, Free PMC Article
    3. crm-1 facilitates BMP signaling to control body size in Caenorhabditis elegans. Fung WY, et al. Dev Biol, 2007 Nov 1. PMID 17869238
    4. Sex determination in the germ line. Ellis R, et al. WormBook, 2007 Mar 5. PMID 18050498, Free PMC Article
    5. A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins. Kamal M, et al. Elife, 2022 Oct 19. PMID 36259463, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cysteine-rich motor neuron 1 protein;Cysteine-rich motor neuron 1 protein-like
    NP_001256210.1
    • Confirmed by transcript evidence
    NP_741616.2
    • Confirmed by transcript evidence
    NP_741617.2
    • Confirmed by transcript evidence
    NP_741618.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10322283..10332112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171530.7 → NP_741617.2  Cysteine-rich motor neuron 1 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741617.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEX3
      Conserved Domains (1) summary
      cl17735
      Location:541 → 592
      VWC; von Willebrand factor type C domain

    2. NM_171529.7 → NP_741616.2  Cysteine-rich motor neuron 1 protein-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741616.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF34
      Conserved Domains (2) summary
      pfam00219
      Location:28 → 76
      IGFBP; Insulin-like growth factor binding protein
      cl17735
      Location:607 → 658
      VWC; von Willebrand factor type C domain

    3. NM_171935.7 → NP_741618.2  Cysteine-rich motor neuron 1 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741618.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBZ2
      Conserved Domains (1) summary
      cl17735
      Location:541 → 592
      VWC; von Willebrand factor type C domain

    4. NM_001269281.4 → NP_001256210.1  Cysteine-rich motor neuron 1 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256210.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6S3
      Conserved Domains (1) summary
      cl17735
      Location:516 → 567
      VWC; von Willebrand factor type C domain

    RNA

    1. NR_132530.1 RNA Sequence

      Status: REVIEWED

    2. NR_132531.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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