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    cft-1 Cystic Fibrosis Transmembrane conductance regulator homolog [ Caenorhabditis elegans ]

    Gene ID: 178939, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cft-1
    Official Full Name
    Cystic Fibrosis Transmembrane conductance regulator homolog
    Primary source
    WormBase:WBGene00000477
    Locus tag
    CELE_C18C4.2
    See related
    AllianceGenome:WB:WBGene00000477
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in excretory cell. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cft-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    20
    Sequence:
    Chromosome: V; NC_003283.11 (5538800..5545789)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene putative peptidyl-tRNA hydrolase 2 Neighboring gene Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 1 Neighboring gene Putative UDP-glucuronosyltransferase ugt-48 Neighboring gene pseudo Neighboring gene GRIP domain-containing protein;Golgin-84 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative genomics and adaptive selection of the ATP-binding-cassette gene family in caenorhabditis species. Zhao Z, et al. Genetics, 2007 Mar. PMID 17194779, Free PMC Article
    2. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article
    3. Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7. Sundaram P, et al. Genetics, 2008 Feb. PMID 18245353, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cystic Fibrosis Transmembrane conductance regulator homolog
    NP_504463.1
    • Product from WormBase gene class cft;
      Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5538800..5545789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072062.5 → NP_504463.1  Cystic Fibrosis Transmembrane conductance regulator homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504463.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95QV2
      Conserved Domains (4) summary
      COG1122
      Location:1012 → 1234
      EcfA2; Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and metabolism, General function prediction only]
      COG1132
      Location:76 → 631
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      cl00549
      Location:93 → 359
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:407 → 607
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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