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    maph-1.1 Microtubule-associated protein homolog maph-1.1 [ Caenorhabditis elegans ]

    Gene ID: 173357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    maph-1.1
    Official Full Name
    Microtubule-associated protein homolog maph-1.1
    Primary source
    WormBase:WBGene00009306
    Locus tag
    CELE_F32A7.5
    See related
    AllianceGenome:WB:WBGene00009306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin binding activity and microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; neuron projection development; and regulation of microtubule depolymerization. Located in microtubule cytoskeleton. Is expressed in body wall musculature; egg-laying apparatus; hypodermis; intestinal cell; and neurons. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and periventricular nodular heterotopia. Orthologous to human MAP1A (microtubule associated protein 1A); MAP1B (microtubule associated protein 1B); and MAP1S (microtubule associated protein 1S). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See maph-1.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (14846476..14850142)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Methyltransferase-like protein 17, mitochondrial Neighboring gene Endoprotease aex-5 Neighboring gene Seven TM Receptor Neighboring gene Myosin-4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interplay Between Polymorphic Short Tandem Repeats and Gene Expression Variation in Caenorhabditis elegans. Zhang G, et al. Mol Biol Evol, 2023 Apr 4. PMID 36999565, Free PMC Article
    2. CeLINC, a fluorescence-based protein-protein interaction assay in Caenorhabditis elegans. Kroll JR, et al. Genetics, 2021 Dec 10. PMID 34849800, Free PMC Article
    3. Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity. He L, et al. Elife, 2020 Apr 15. PMID 32293562, Free PMC Article
    4. Epidermal PAR-6 and PKC-3 are essential for larval development of C. elegans and organize non-centrosomal microtubules. Castiglioni VG, et al. Elife, 2020 Dec 10. PMID 33300872, Free PMC Article
    5. DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Lin XX, et al. Nat Commun, 2018 Oct 23. PMID 30353013, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Microtubule-associated protein homolog maph-1.1
    NP_001021436.1
    • Confirmed by transcript evidence
    NP_001021437.1
    • Confirmed by transcript evidence
    NP_001021438.1
    • Confirmed by transcript evidence
    NP_001252456.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14846476..14850142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026267.3 → NP_001021438.1  Microtubule-associated protein homolog maph-1.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021438.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91859
      Conserved Domains (1) summary
      PHA03247
      Location:229 → 533
      PHA03247; large tegument protein UL36; Provisional

    2. NM_001026266.3 → NP_001021437.1  Microtubule-associated protein homolog maph-1.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021437.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91859
      Conserved Domains (1) summary
      PRK12323
      Location:216 → 318
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional

    3. NM_001265527.4 → NP_001252456.1  Microtubule-associated protein homolog maph-1.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252456.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91859
      Conserved Domains (1) summary
      PHA03247
      Location:217 → 489
      PHA03247; large tegument protein UL36; Provisional

    4. NM_001026265.3 → NP_001021436.1  Microtubule-associated protein homolog maph-1.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021436.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2FLK1, P91859, Q7YXB8, Q7YXB9
      Conserved Domains (1) summary
      cl26464
      Location:229 → 533
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91859.1

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