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    abt-1 ABC transporter domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 182849, updated on 9-Dec-2024

    Summary

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    Official Symbol
    abt-1
    Official Full Name
    ABC transporter domain-containing protein
    Primary source
    WormBase:WBGene00000019
    Locus tag
    CELE_C24F3.5
    See related
    AllianceGenome:WB:WBGene00000019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human ABCA5 (ATP binding cassette subfamily A member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See abt-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    28
    Sequence:
    Chromosome: IV; NC_003282.8 (10206189..10214911, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene GON-4-like protein Neighboring gene pseudo Neighboring gene Serpentine receptor class gamma Neighboring gene Glutamine-dependent NAD(+) synthetase;NAD/GMP synthase domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Translocating chain-associated membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ABC transporter gene family of Caenorhabditis elegans has implications for the evolutionary dynamics of multidrug resistance in eukaryotes. Sheps JA, et al. Genome Biol, 2004. PMID 15003118, Free PMC Article
    2. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article
    3. Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7. Sundaram P, et al. Genetics, 2008 Feb. PMID 18245353, Free PMC Article
    4. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ABC transporter domain-containing protein
    NP_001293854.1
    • Confirmed by transcript evidence
    NP_001293855.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10206189..10214911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306925.2 → NP_001293854.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293854.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6EZS3
      Conserved Domains (4) summary
      TIGR01257
      Location:256 → 676
      rim_protein; retinal-specific rim ABC transporter
      COG1131
      Location:1328 → 1491
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:917 → 1176
      ABC2_membrane_3; ABC-2 family transporter protein
      cl38936
      Location:474 → 677
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001306926.3 → NP_001293855.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293855.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FN28
      Conserved Domains (4) summary
      TIGR01257
      Location:177 → 597
      rim_protein; retinal-specific rim ABC transporter
      COG1131
      Location:1249 → 1412
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:838 → 1097
      ABC2_membrane_3; ABC-2 family transporter protein
      cl38936
      Location:395 → 598
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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