U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    hir-1 receptor protein-tyrosine kinase [ Caenorhabditis elegans ]

    Gene ID: 178936, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    hir-1
    Official Full Name
    receptor protein-tyrosine kinase
    Primary source
    WormBase:WBGene00016059
    Locus tag
    CELE_C24G6.2
    See related
    AllianceGenome:WB:WBGene00016059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in cell periphery and membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in hypodermis and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See hir-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    19
    Sequence:
    Chromosome: V; NC_003283.11 (5523727..5530733)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MMS19 nucleotide excision repair protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ground-like domain-containing protein Neighboring gene putative peptidyl-tRNA hydrolase 2 Neighboring gene Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury. Vozdek R, et al. Sci Signal, 2018 Oct 2. PMID 30279166
    2. Acquired stress resilience through bacteria-to-nematode interdomain horizontal gene transfer. Pandey T, et al. EMBO J, 2023 Dec 11. PMID 37953666, Free PMC Article
    3. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. Wang C, et al. Nat Commun, 2022 Nov 10. PMID 36357390, Free PMC Article
    4. Mediator subunit MDT-15 promotes expression of propionic acid breakdown genes to prevent embryonic lethality in Caenorhabditis elegans. Goh GYS, et al. G3 (Bethesda), 2023 Jun 1. PMID 37075089, Free PMC Article
    5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    receptor protein-tyrosine kinase
    NP_504458.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5523727..5530733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072057.7 → NP_504458.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76385
      Conserved Domains (2) summary
      cd00192
      Location:547 → 842
      PTKc; Catalytic domain of Protein Tyrosine Kinases
      pfam00041
      Location:85 → 163
      fn3; Fibronectin type III domain

    RNA

    1. NR_155252.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools