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    mrp-6 Multidrug resistance-associated protein lethal(2)03659 [ Caenorhabditis elegans ]

    Gene ID: 180691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mrp-6
    Official Full Name
    Multidrug resistance-associated protein lethal(2)03659
    Primary source
    WormBase:WBGene00003412
    Locus tag
    CELE_F20B6.3
    See related
    AllianceGenome:WB:WBGene00003412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in hypodermis; intestine; and nervous system. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mrp-6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    18
    Sequence:
    Chromosome: X; NC_003284.9 (4177989..4186756, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene MD-2-related lipid-recognition domain-containing protein Neighboring gene ncRNA Neighboring gene V-type proton ATPase subunit B 1 Neighboring gene Envelope glycoprotein UL132

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gut efflux pump MRP-1 exports oxidized glutathione as a danger signal that stimulates behavioral immunity and aversive learning. Lalsiamthara J, et al. Commun Biol, 2022 May 5. PMID 35513700, Free PMC Article
    2. The role of several ABC transporter genes in ivermectin resistance in Caenorhabditis elegans. Yan R, et al. Vet Parasitol, 2012 Dec 21. PMID 22840641
    3. An RNAi screen identifies genes that regulate GABA synapses. Vashlishan AB, et al. Neuron, 2008 May 8. PMID 18466746
    4. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article
    5. Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7. Sundaram P, et al. Genetics, 2008 Feb. PMID 18245353, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Multidrug resistance-associated protein lethal(2)03659
    NP_001362008.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4177989..4186756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001375011.2 → NP_001362008.1  Multidrug resistance-associated protein lethal(2)03659 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19625
      Conserved Domains (1) summary
      TIGR00957
      Location:126 → 1389
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    Nucleotide Protein
    Heading Accession and Version

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