cpz-1 Cathepsin Z-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cpz-1
Official Full Name: Cathepsin Z-1
Primary source: WormBase:WBGene00000788
Locus tag: CELE_F32B5.8
See related: AllianceGenome:WB:WBGene00000788
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including ecdysis, collagen and cuticulin-based cuticle; gonad morphogenesis; and post-embryonic body morphogenesis. Located in collagen and cuticulin-based cuticle extracellular matrix; extracellular space; and yolk granule. Is expressed in several structures, including cuticle; hypodermal cell; intestine; pharynx; and vulva. Orthologous to human CTSZ (cathepsin Z). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cpz-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (2686640..2689429, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cathepsin Z has a critical role during nematode development
Title: The Caenorhabditis elegans cathepsin Z-like cysteine protease, Ce-CPZ-1, has a multifunctional role during the worms' development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F32B5.8 (e-PCR)
- UniSTS:319296

STS1-164 (e-PCR)
- UniSTS:241652

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ecdysis, collagen and cuticulin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen and cuticulin-based cuticle extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in yolk granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Cathepsin Z-1

NP_001364831.1

Confirmed by transcript evidence

NP_491023.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

2686640..2689429 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058622.7 → NP_491023.2 Cathepsin Z-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491023.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A078BPL2, G5EGP8

Conserved Domains (1) summary

cd02698
Location:65 → 305

Peptidase_C1A_CathepsinX; Cathepsin X; the only papain-like lysosomal cysteine peptidase exhibiting carboxymonopeptidase activity. It can also act as a carboxydipeptidase, like cathepsin B, but has been shown to preferentially cleave substrates through a monopeptidyl ...
NM_001377810.2 → NP_001364831.1 Cathepsin Z-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl23744
Location:1 → 169

Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...