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    dhs-13 DeHydrogenases, Short chain [ Caenorhabditis elegans ]

    Gene ID: 178658, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhs-13
    Official Full Name
    DeHydrogenases, Short chain
    Primary source
    WormBase:WBGene00000976
    Locus tag
    CELE_F36H9.3
    See related
    AllianceGenome:WB:WBGene00000976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carbonyl reductase (NADPH) activity. Orthologous to several human genes including DHRS2 (dehydrogenase/reductase 2); DHRS4 (dehydrogenase/reductase 4); and DHRS4L2 (dehydrogenase/reductase 4 like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhs-13 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (1765311..1771734, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene C-type lectin domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene UPAR/Ly6 domain-containing protein Neighboring gene TIL domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bioinformatic and biochemical characterization of DCXR and DHRS2/4 from Caenorhabditis elegans. Kisiela M, et al. Chem Biol Interact, 2011 May 30. PMID 21300042
    2. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. Gabrielli F, et al. Gene, 2012 Dec 15. PMID 23036705
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DeHydrogenases, Short chain
    NP_503501.1
    • Product from WormBase gene class dhs;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1765311..1771734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071100.2 → NP_503501.1  DeHydrogenases, Short chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16619
      Conserved Domains (2) summary
      PRK07231
      Location:9 → 253
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
      cl21454
      Location:9 → 257
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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