R11D1.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: R11D1.1
Official Full Name: WD_REPEATS_REGION domain-containing protein
Primary source: WormBase:WBGene00011242
Locus tag: CELE_R11D1.1
See related: AllianceGenome:WB:WBGene00011242
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human DCAF5 (DDB1 and CUL4 associated factor 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See R11D1.1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (12704377..12707766)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R11D1.1 (e-PCR)
- UniSTS:321643

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in negative regulation of fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD_REPEATS_REGION domain-containing protein

NP_001263874.1

Confirmed by transcript evidence

NP_001263875.1

Confirmed by transcript evidence

NP_001379144.1

Confirmed by transcript evidence

NP_506171.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12704377..12707766

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001276945.4 → NP_001263874.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263874.1

Status: REVIEWED

UniProtKB/TrEMBL

L8EC35

Conserved Domains (3) summary

COG2319
Location:39 → 399

WD40; WD40 repeat [General function prediction only]

sd00039
Location:69 → 111

7WD40; WD40 repeat [structural motif]

cl02567
Location:58 → 395

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_073770.6 → NP_506171.2 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506171.2

Status: REVIEWED

UniProtKB/TrEMBL

Q21934

Conserved Domains (3) summary

COG2319
Location:39 → 399

WD40; WD40 repeat [General function prediction only]

sd00039
Location:69 → 111

7WD40; WD40 repeat [structural motif]

cl02567
Location:58 → 395

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001392630.1 → NP_001379144.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q7JLF4

Conserved Domains (2) summary

COG2319
Location:58 → 401

WD40; WD40 repeat [General function prediction only]

sd00039
Location:69 → 110

7WD40; WD40 repeat [structural motif]
NM_001276946.4 → NP_001263875.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263875.1

Status: REVIEWED

UniProtKB/TrEMBL

L8E955

Conserved Domains (4) summary

smart00320
Location:357 → 394

WD40; WD40 repeats

COG2319
Location:58 → 401

WD40; WD40 repeat [General function prediction only]

sd00039
Location:69 → 110

7WD40; WD40 repeat [structural motif]

cl02567
Location:58 → 211

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...