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    sodh-2 Alcohol dehydrogenase 2 [ Caenorhabditis elegans ]

    Gene ID: 179628, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sodh-2
    Official Full Name
    Alcohol dehydrogenase 2
    Primary source
    WormBase:WBGene00010791
    Locus tag
    CELE_K12G11.4
    See related
    AllianceGenome:WB:WBGene00010791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable alcohol dehydrogenase (NAD+) activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sodh-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (11889581..11891243, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene STAS domain-containing protein Neighboring gene STAS domain-containing protein Neighboring gene ncRNA Neighboring gene Alcohol dehydrogenase 1 Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular evolution and functional divergence of alcohol dehydrogenases in animals, fungi and plants. Thompson CE, et al. Genet Mol Biol, 2018. PMID 29668010, Free PMC Article
    2. Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans. Menzel R, et al. J Mol Biol, 2007 Jun 29. PMID 17499272
    3. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Murphy CT, et al. Nature, 2003 Jul 17. PMID 12845331
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Alcohol dehydrogenase 2
    NP_505992.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11889581..11891243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073591.5 → NP_505992.1  Alcohol dehydrogenase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505992.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45687
      Conserved Domains (2) summary
      cd08297
      Location:10 → 348
      CAD3; Cinnamyl alcohol dehydrogenases (CAD)
      COG1064
      Location:7 → 349
      AdhP; D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45687.1

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