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    inx-11 Innexin;Innexin-11 [ Caenorhabditis elegans ]

    Gene ID: 179710, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inx-11
    Official Full Name
    Innexin;Innexin-11
    Primary source
    WormBase:WBGene00002133
    Locus tag
    CELE_W04D2.3
    See related
    AllianceGenome:WB:WBGene00002133
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable gap junction hemi-channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Located in gap junction. Is expressed in several structures, including egg-laying apparatus; epithelial cell; pharynx; spermatid; and tail neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inx-11 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (12487234..12493269)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Alpha-actinin, sarcomeric Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class T Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S11 Neighboring gene C2H2-type domain-containing protein Neighboring gene PWI domain-containing protein;RRM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Innexins in C. elegans. Starich T, et al. Cell Commun Adhes, 2001. PMID 12064609
    2. Six innexins contribute to electrical coupling of C. elegans body-wall muscle. Liu P, et al. PLoS One, 2013. PMID 24130800, Free PMC Article
    3. Presynaptic coupling by electrical synapses coordinates a rhythmic behavior by synchronizing the activities of a neuron pair. Choi U, et al. Proc Natl Acad Sci U S A, 2021 May 18. PMID 33972428, Free PMC Article
    4. The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. Barnes TM, et al. J Neurochem, 1997 Dec. PMID 9375655
    5. The role of gap junctions in Caenorhabditis elegans oocyte maturation and fertilization. Whitten SJ, et al. Dev Biol, 2007 Jan 15. PMID 16982048

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables gap junction hemi-channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Innexin;Innexin-11
    NP_001256426.1
    • Confirmed by transcript evidence
    NP_001359736.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12487234..12493269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373129.3 → NP_001359736.1  Innexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9IY29, T2DL39, T2DLM4
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 383
      Innexin

    2. NM_001269497.3 → NP_001256426.1  Innexin-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256426.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23157
      UniProtKB/TrEMBL
      T2DL39
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 385
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23157.1

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