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    svh-1 Serine protease svh-1 [ Caenorhabditis elegans ]

    Gene ID: 182375, updated on 9-Dec-2024

    Summary

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    Official Symbol
    svh-1
    Official Full Name
    Serine protease svh-1
    Primary source
    WormBase:WBGene00006620
    Locus tag
    CELE_C07G1.1
    See related
    AllianceGenome:WB:WBGene00006620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in several processes, including positive regulation of gonad development; positive regulation of nematode pharyngeal pumping; and protein destabilization. Predicted to be located in extracellular space. Is expressed in ADLL and ADLR. Human ortholog(s) of this gene implicated in enterokinase deficiency. Orthologous to human TMPRSS15 (transmembrane serine protease 15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See svh-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    16
    Sequence:
    Chromosome: IV; NC_003282.8 (8206614..8213741)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Hepatocyte growth factor-regulated tyrosine kinase substrate Neighboring gene ncRNA Neighboring gene Histone deacetylase HDT1 Neighboring gene ELM2 domain-containing protein Neighboring gene Ion transport domain-containing protein Neighboring gene Glutathione peroxidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans F-Box Protein Promotes Axon Regeneration by Inducing Degradation of the Mad Transcription Factor. Shimizu T, et al. J Neurosci, 2021 Mar 17. PMID 33514673, Free PMC Article
    2. C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways. Hisamoto N, et al. J Neurosci, 2019 Jul 17. PMID 31109965, Free PMC Article
    3. Axon Regeneration Is Regulated by Ets-C/EBP Transcription Complexes Generated by Activation of the cAMP/Ca2+ Signaling Pathways. Li C, et al. PLoS Genet, 2015 Oct. PMID 26484536, Free PMC Article
    4. The C. elegans HGF/plasminogen-like protein SVH-1 has protease-dependent and -independent functions. Hisamoto N, et al. Cell Rep, 2014 Dec 11. PMID 25464847
    5. TDP2 negatively regulates axon regeneration by inducing SUMOylation of an Ets transcription factor. Sakai Y, et al. EMBO Rep, 2019 Oct 4. PMID 31393064, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SVH-1 acts as both a growth factor and a protease in C. elegans.
      Title: The C. elegans HGF/plasminogen-like protein SVH-1 has protease-dependent and -independent functions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon regeneration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine protease svh-1
    NP_501379.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8206614..8213741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068978.6 → NP_501379.2  Serine protease svh-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501379.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1AGA0, Q17800
      Conserved Domains (6) summary
      smart00192
      Location:558 → 590
      LDLa; Low-density lipoprotein receptor domain class A
      smart00130
      Location:227 → 306
      KR; Kringle domain
      cd00112
      Location:320 → 355
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:713 → 945
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cd01099
      Location:373 → 434
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
      cl02509
      Location:599 → 681
      SRCR_2; Scavenger receptor cysteine-rich domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17800.2

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