sox-2 HMG box domain-containing protein;Transcription factor sox-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sox-2
Official Full Name: HMG box domain-containing protein;Transcription factor sox-2
Primary source: WormBase:WBGene00004949
Locus tag: CELE_K08A8.2
See related: AllianceGenome:WB:WBGene00004949
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron fate specification. Predicted to be active in nucleus. Is expressed in several structures, including amphid neurons; head neurons; hypodermis; neuroblasts; and rectal epithelial cell. Human ortholog(s) of this gene implicated in X-linked panhypopituitarism; breast cancer; nasal cavity cancer; and syndromic microphthalmia 3. Orthologous to several human genes including SOX2 (SRY-box transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sox-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (7458282..7463736, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In this study, a mechanism was identified of signaling between homeodomain-like transcription factor NSY-7 , SLO BK potassium channels, HMG box domain-containing protein (sox-2), and transportin 1 in Caenorhabditis elegans AWC olfactory neuron pair subtype differentiation.
Title: A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor.
The role of SOX2 in neurogenesis and stem cell differentiation has been discussed.
Title: Sox2 goes beyond stem cell biology.
SOX-2 partners with different transcription factors to diversify postmitotic olfactory cell types.
Title: Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG-box transcription factor SOX-2.
genetic analyses revealed the requirement of members of the NODE complex recently identified in embryonic stem (ES) cells, and of the OCT4 partner sox-2, for the initiation of this natural direct reprogramming event
Title: Members of the NODE (Nanog and Oct4-associated deacetylase) complex and SOX-2 promote the initiation of a natural cellular reprogramming event in vivo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K08A8.2 (e-PCR)
- UniSTS:315275

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: HMG box domain-containing protein;Transcription factor sox-2

NP_001379596.1

Confirmed by transcript evidence

NP_741836.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7458282..7463736 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171725.9 → NP_741836.1 Transcription factor sox-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741836.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21305

Conserved Domains (1) summary

cd01388
Location:59 → 130

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001392801.1 → NP_001379596.1 HMG box domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8IG08

Conserved Domains (1) summary

cl00082
Location:1 → 46

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...