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    gcy-31 Soluble guanylate cyclase gcy-31;guanylate cyclase [ Caenorhabditis elegans ]

    Gene ID: 191655, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-31
    Official Full Name
    Soluble guanylate cyclase gcy-31;guanylate cyclase
    Primary source
    WormBase:WBGene00001551
    Locus tag
    CELE_T07D1.1
    See related
    AllianceGenome:WB:WBGene00001551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables oxygen sensor activity. Involved in response to oxygen levels. Predicted to be located in cytoplasm. Predicted to be part of guanylate cyclase complex, soluble. Is expressed in head. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-31 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (2419955..2427504, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene GLutamate Receptor family (AMPA) Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RING-Gid-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Guanylate cyclases link serotoninergic signaling to modulate ethanol-induced food intake in C. elegans. Wang X, et al. Biochem Biophys Res Commun, 2021 Aug 27. PMID 34133999
    2. Oxygen sensing neurons and neuropeptides regulate survival after anoxia in developing C. elegans. Flibotte JJ, et al. PLoS One, 2014. PMID 24967811, Free PMC Article
    3. Can oxygen anosmia extend lifespan? Abergel R, et al. Aging (Albany NY), 2017 Nov 30. PMID 29190215, Free PMC Article
    4. A novel role for the zinc-finger transcription factor EGL-46 in the differentiation of gas-sensing neurons in Caenorhabditis elegans. Rojo Romanos T, et al. Genetics, 2015 Jan. PMID 25395666, Free PMC Article
    5. Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior. Bretscher AJ, et al. Neuron, 2011 Mar 24. PMID 21435556, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitric oxide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen sensor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitric oxide-cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxygen levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Soluble guanylate cyclase gcy-31;guanylate cyclase
    NP_001024888.1
    • Confirmed by transcript evidence
    NP_001024889.1
    • Confirmed by transcript evidence
    NP_001024890.1
    • Confirmed by transcript evidence
    NP_001317860.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2419955..2427504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029718.2 → NP_001024889.1  Soluble guanylate cyclase gcy-31 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024889.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86C56, Q86C57, Q86C58
      Conserved Domains (4) summary
      smart00044
      Location:397 → 592
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:429 → 613
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:2 → 164
      HNOB; Haem-NO-binding
      pfam07701
      Location:221 → 418
      HNOBA; Heme NO binding associated

    2. NM_001029717.2 → NP_001024888.1  Soluble guanylate cyclase gcy-31 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024888.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86C56
      Conserved Domains (4) summary
      smart00044
      Location:289 → 484
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:321 → 505
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:2 → 164
      HNOB; Haem-NO-binding
      pfam07701
      Location:229 → 310
      HNOBA; Heme NO binding associated

    3. NM_001029719.1 → NP_001024890.1  Soluble guanylate cyclase gcy-31 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024890.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86C56
      Conserved Domains (4) summary
      smart00044
      Location:273 → 468
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:305 → 489
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:10 → 40
      HNOB; Haem-NO-binding
      pfam07701
      Location:97 → 294
      HNOBA; Heme NO binding associated

    4. NM_001330893.1 → NP_001317860.1  guanylate cyclase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A163UTN8
      Conserved Domains (3) summary
      smart00044
      Location:360 → 555
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam07701
      Location:184 → 381
      HNOBA; Heme NO binding associated
      pfam07700
      Location:6 → 127
      HNOB; Haem-NO-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86C56.2

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