W04A8.1 BRCT domain-containing protein;protein-serine/threonine phosphatase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: W04A8.1
Official Full Name: BRCT domain-containing protein;protein-serine/threonine phosphatase
Primary source: WormBase:WBGene00012236
Locus tag: CELE_W04A8.1
See related: AllianceGenome:WB:WBGene00012236
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in breast cancer; endometrial cancer; microcephaly; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 1. Orthologous to human MCPH1 (microcephalin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See W04A8.1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (13835327..13840087, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W04A8.1 (e-PCR)
- UniSTS:315159

W04A8.2 (e-PCR)
- UniSTS:317614

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BRCT domain-containing protein;protein-serine/threonine phosphatase

NP_001391096.1

Confirmed by transcript evidence

NP_001391098.1

Confirmed by transcript evidence

NP_001417600.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

13835327..13840087 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001404216.1 → NP_001391096.1 protein-serine/threonine phosphatase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4Q990, Q9XUM4
NM_001404217.1 → NP_001391098.1 protein-serine/threonine phosphatase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QF03, Q9XUM4
NM_001430674.1 → NP_001417600.1 BRCT domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QAU8, B3WFY2