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    unc-1 Band 7 domain-containing protein;Protein unc-1 [ Caenorhabditis elegans ]

    Gene ID: 180458, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-1
    Official Full Name
    Band 7 domain-containing protein;Protein unc-1
    Primary source
    WormBase:WBGene00006741
    Locus tag
    CELE_K03E6.5
    See related
    AllianceGenome:WB:WBGene00006741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ion channel regulator activity. Involved in positive regulation of cell communication by electrical coupling and response to xenobiotic stimulus. Located in axon and gap junction. Is expressed in several structures, including enteric muscle; ganglia; head neurons; somatic nervous system; and vulval muscle. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (1057487..1062453, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene B9 domain-containing protein 1 Neighboring gene LIM/homeobox protein lim-6 Neighboring gene Profilin-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unc-1: a stomatin homologue controls sensitivity to volatile anesthetics in Caenorhabditis elegans. Rajaram S, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671752, Free PMC Article
    2. Tail clamp responses in stomatin knockout mice compared with mobility assays in Caenorhabditis elegans during exposure to diethyl ether, halothane, and isoflurane. Sedensky MM, et al. Anesthesiology, 2006 Sep. PMID 16931982
    3. Dissection of neuronal gap junction circuits that regulate social behavior in Caenorhabditis elegans. Jang H, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28143932, Free PMC Article
    4. Gap junctions synchronize action potentials and Ca2+ transients in Caenorhabditis elegans body wall muscle. Liu P, et al. J Biol Chem, 2011 Dec 23. PMID 22033926, Free PMC Article
    5. UNC-1 regulates gap junctions important to locomotion in C. elegans. Chen B, et al. Curr Biol, 2007 Aug 7. PMID 17658257, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeted rescue experiments suggest that UNC-9 and UNC-1 function predominantly in neurons to control locomotion.
      Title: UNC-1 regulates gap junctions important to locomotion in C. elegans.
    2. unc-1, unc-24, and ssu-1 are neuronal stomatin-like proteins sharing regulatory roles with a sulfotransferase enzyme
      Title: Sulfated signal from ASJ sensory neurons modulates stomatin-dependent coordination in Caenorhabditis elegans.
    3. homologues of Hyperkinetic and K channel regulator 1 proteins interact with and modify unc-103 function; effect of mutations on function and physiology
      Title: In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.
    4. Mutations in the unc-24 gene alter the distribution of UNC-1 in lipid rafts.
      Title: A stomatin and a degenerin interact in lipid rafts of the nervous system of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ion channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cell communication by electrical coupling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Band 7 domain-containing protein;Protein unc-1
    NP_001123162.1
    • Confirmed by transcript evidence
    NP_508202.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1057487..1062453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129690.5 → NP_001123162.1  Band 7 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED08
      Conserved Domains (1) summary
      cl19107
      Location:79 → 279
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    2. NM_075801.7 → NP_508202.1  Protein unc-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21190
      Conserved Domains (2) summary
      smart00244
      Location:54 → 203
      PHB; prohibitin homologues
      cl19107
      Location:75 → 275
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21190.2

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