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    tba-6 Tubulin alpha chain [ Caenorhabditis elegans ]

    Gene ID: 172717, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tba-6
    Official Full Name
    Tubulin alpha chain
    Primary source
    WormBase:WBGene00006532
    Locus tag
    CELE_F32H2.9
    See related
    AllianceGenome:WB:WBGene00006532
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be active in cytoplasm and microtubule. Is expressed in HSN; ciliated neurons; intestine; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tba-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (8994002..8998604)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene ncRNA Neighboring gene Coiled-coil domain-containing protein Neighboring gene Fatty acid synthase Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene t-SNARE coiled-coil homology domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and three-dimensional structure prediction of a novel alpha-tubulin in Caenorhabditis elegans. Baleanu-Gogonea C, et al. J Cell Mol Med, 2000 Jul-Sep. PMID 12167287, Free PMC Article
    2. Cell-Specific α-Tubulin Isotype Regulates Ciliary Microtubule Ultrastructure, Intraflagellar Transport, and Extracellular Vesicle Biology. Silva M, et al. Curr Biol, 2017 Apr 3. PMID 28318980, Free PMC Article
    3. Specific alpha- and beta-tubulin isotypes optimize the functions of sensory Cilia in Caenorhabditis elegans. Hurd DD, et al. Genetics, 2010 Jul. PMID 20421600, Free PMC Article
    4. Expression Patterns and Levels of All Tubulin Isotypes Analyzed in GFP Knock-In C. elegans Strains. Nishida K, et al. Cell Struct Funct, 2021 Jun 30. PMID 33967119, Free PMC Article
    5. Microtubule plus-end dynamics link wound repair to the innate immune response. Taffoni C, et al. Elife, 2020 Jan 29. PMID 31995031, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using C. elegans, the authors show that alpha-tubulin isotype TBA-6 sculpts 18 A- and B-tubule singlets from nine ciliary A-B doublet microtubules in cephalic male (CEM) neurons.
      Title: Cell-Specific α-Tubulin Isotype Regulates Ciliary Microtubule Ultrastructure, Intraflagellar Transport, and Extracellular Vesicle Biology.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tubulin alpha chain
    NP_492419.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8994002..8998604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060018.5 → NP_492419.2  Tubulin alpha chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492419.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91873, Q9GRE9
      Conserved Domains (2) summary
      PTZ00335
      Location:8 → 453
      PTZ00335; tubulin alpha chain; Provisional
      cd02186
      Location:8 → 441
      alpha_tubulin; The alpha-tubulin family
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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