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    DH11.5 C2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565199, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DH11.5
    Official Full Name
    C2 domain-containing protein
    Primary source
    WormBase:WBGene00008438
    Locus tag
    CELE_DH11.5
    See related
    AllianceGenome:WB:WBGene00008438
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and regulation of synaptic vesicle exocytosis. Predicted to be active in axon; plasma membrane; and secretory vesicle. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DH11.5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    19
    Sequence:
    Chromosome: II; NC_003280.10 (7976608..7994665)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene P-GlycoProtein related Neighboring gene Putative glutaminase 2;glutaminase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Translational control of the oogenic program by components of OMA ribonucleoprotein particles in Caenorhabditis elegans. Spike CA, et al. Genetics, 2014 Dec. PMID 25261697, Free PMC Article
    2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dense core granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C2 domain-containing protein
    NP_001254131.1
    • Confirmed by transcript evidence
    NP_001254132.1
    • Partially confirmed by transcript evidence
    NP_871972.1
    • Confirmed by transcript evidence
    NP_871973.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7976608..7994665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267202.3 → NP_001254131.1  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254131.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDP5
      Conserved Domains (1) summary
      cd00276
      Location:671 → 822
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin

    2. NM_182172.7 → NP_871972.1  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871972.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFC6

    3. NM_182173.6 → NP_871973.1  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4L8

    4. NM_001267203.3 → NP_001254132.1  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254132.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19016
      Conserved Domains (1) summary
      cl14603
      Location:220 → 371
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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